Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control.


Journal Article

Orchestrated biological materials such as enzymes and growth factors regulate the growth of tissues and organs. A chirality-controlled, single-protein technology is devised to tailor the spatiotemporally defined delivery of therapeutic proteins in response to natural enzymes present at wound sites. Sustained delivery of one protein and sequential delivery of two proteins are demonstrated for stroke and skin wound healing.

Full Text

Duke Authors

Cited Authors

  • Zhu, S; Nih, L; Carmichael, ST; Lu, Y; Segura, T

Published Date

  • June 2015

Published In

Volume / Issue

  • 27 / 24

Start / End Page

  • 3620 - 3625

PubMed ID

  • 25962336

Pubmed Central ID

  • 25962336

Electronic International Standard Serial Number (EISSN)

  • 1521-4095

International Standard Serial Number (ISSN)

  • 0935-9648

Digital Object Identifier (DOI)

  • 10.1002/adma.201500417


  • eng