An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules.

Published

Journal Article

An efficient strategy for the intracellular delivery of proteins was developed based on assembling proteins with a self-crosslinkable polymer. Such a disulfide-crosslinking structure enhances the stability of the protein-polymer assembly, and also allows effective dissociation of the assembly in response to glutathione, which allows effective delivery of various proteins with high intracellular bioactivity.

Full Text

Published version (via Digital Object Identifier)
Pubmed Central version

Duke Authors

Segura, Tatiana

Cited Authors

Li, J; Zhang, L; Liu, Y; Wen, J; Wu, D; Xu, D; Segura, T; Jin, J; Lu, Y; Wang, H

Published Date

November 2016

Published In

Chemical Communications

Volume / Issue

52 / 93

Start / End Page

13608 - 13611

PubMed ID

27808287

Pubmed Central ID

27808287

Electronic International Standard Serial Number (EISSN)

1364-548X

International Standard Serial Number (ISSN)

1359-7345

Digital Object Identifier (DOI)

10.1039/c6cc05099a

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