An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules.


Journal Article

An efficient strategy for the intracellular delivery of proteins was developed based on assembling proteins with a self-crosslinkable polymer. Such a disulfide-crosslinking structure enhances the stability of the protein-polymer assembly, and also allows effective dissociation of the assembly in response to glutathione, which allows effective delivery of various proteins with high intracellular bioactivity.

Full Text

Duke Authors

Cited Authors

  • Li, J; Zhang, L; Liu, Y; Wen, J; Wu, D; Xu, D; Segura, T; Jin, J; Lu, Y; Wang, H

Published Date

  • November 2016

Published In

Volume / Issue

  • 52 / 93

Start / End Page

  • 13608 - 13611

PubMed ID

  • 27808287

Pubmed Central ID

  • 27808287

Electronic International Standard Serial Number (EISSN)

  • 1364-548X

International Standard Serial Number (ISSN)

  • 1359-7345

Digital Object Identifier (DOI)

  • 10.1039/c6cc05099a


  • eng