Short-term sPECAM-Fc treatment ameliorates EAE while chronic use hastens onset of symptoms.

Published

Journal Article

The homophilic cell adhesion molecule PECAM-1 is a major participant in the migration of leukocytes across endothelium. We examined the ability of a chimeric soluble PECAM-1 fused to human IgG-Fc to impair leukocyte entry through the blood-brain barrier and reduce CNS autoimmunity. sPECAM-Fc impaired migration of lymphocytes across brain endothelial monolayers and diminished the severity of EAE, an experimental model of MS, when administered at the onset of symptoms. However, in mice transgenic for sPECAM-Fc, the chronically elevated levels of sPECAM-Fc hastened onset of EAE disease without significantly changing clinical score severity. Our data suggest that short-term treatment of diseases like MS with sPECAM-Fc has therapeutic potential.

Full Text

Cited Authors

  • Reinke, EK; Lee, J; Zozulya, A; Karman, J; Muller, WA; Sandor, M; Fabry, Z

Published Date

  • May 2007

Published In

Volume / Issue

  • 186 / 1-2

Start / End Page

  • 86 - 93

PubMed ID

  • 17467062

Pubmed Central ID

  • 17467062

Electronic International Standard Serial Number (EISSN)

  • 1872-8421

International Standard Serial Number (ISSN)

  • 0165-5728

Digital Object Identifier (DOI)

  • 10.1016/j.jneuroim.2007.03.014

Language

  • eng