Substance P receptor mediated maintenance of chronic inflammation in EAE.

Journal Article (Journal Article)

Substance P (SP) is a modulatory, pro-inflammatory neuropeptide. We investigated the role of the SP receptor, neurokinin-1 (NK-1), in EAE. Our data show that in the chronic phase, mice lacking NK-1 have improved mobility and decreased numbers of LFA-1 high CD4+ T cells and MOG-specific, IFN-gamma producing CD4+ T cells. SR140333, an NK-1 antagonist, administered alone during the chronic phase of EAE was not sufficient to ameliorate symptoms. These results indicate that SP, through NK-1, contributes to maintenance of CNS inflammation, and combining NK-1 antagonists with conventional anti-inflammatory treatments may enhance the success of treatments for diseases like multiple sclerosis.

Full Text

Duke Authors

Cited Authors

  • Reinke, EK; Johnson, MJ; Ling, C; Karman, J; Lee, J; Weinstock, JV; Sandor, M; Fabry, Z

Published Date

  • November 2006

Published In

Volume / Issue

  • 180 / 1-2

Start / End Page

  • 117 - 125

PubMed ID

  • 16942803

Electronic International Standard Serial Number (EISSN)

  • 1872-8421

International Standard Serial Number (ISSN)

  • 0165-5728

Digital Object Identifier (DOI)

  • 10.1016/j.jneuroim.2006.07.010


  • eng