Histone modifications and chromatin organization in prostate cancer.
Journal Article (Journal Article;Review)
Epigenetic mechanisms, including histone modifications, nucleosomal remodeling and chromosomal looping, contribute to the onset and progression of prostate cancer. Recent technical advances significantly increase our understanding of the genome-wide epigenetic regulation of gene expression in prostate cancer. Aberrant genomic distribution and global level of histone modifications, nucleosome repositioning at the gene promoter and enhancer regions, as well as androgen receptor-mediated chromosomal looping may lead to the silencing of tumor suppressor genes and the activation of proto-oncogenes. In addition, androgen receptor-induced chromosomal looping facilitates recurrent gene fusion in prostate cancer. Studies in epigenetic regulation have translational implications in the identification of new biomarkers and the development of new therapies in prostate cancer.
Full Text
Duke Authors
Cited Authors
- Chen, Z; Wang, L; Wang, Q; Li, W
Published Date
- August 2010
Published In
Volume / Issue
- 2 / 4
Start / End Page
- 551 - 560
PubMed ID
- 21318127
Pubmed Central ID
- PMC3035388
Electronic International Standard Serial Number (EISSN)
- 1750-192X
Digital Object Identifier (DOI)
- 10.2217/epi.10.31
Language
- eng
Conference Location
- England