Histone modifications and chromatin organization in prostate cancer.

Journal Article (Journal Article;Review)

Epigenetic mechanisms, including histone modifications, nucleosomal remodeling and chromosomal looping, contribute to the onset and progression of prostate cancer. Recent technical advances significantly increase our understanding of the genome-wide epigenetic regulation of gene expression in prostate cancer. Aberrant genomic distribution and global level of histone modifications, nucleosome repositioning at the gene promoter and enhancer regions, as well as androgen receptor-mediated chromosomal looping may lead to the silencing of tumor suppressor genes and the activation of proto-oncogenes. In addition, androgen receptor-induced chromosomal looping facilitates recurrent gene fusion in prostate cancer. Studies in epigenetic regulation have translational implications in the identification of new biomarkers and the development of new therapies in prostate cancer.

Full Text

Duke Authors

Cited Authors

  • Chen, Z; Wang, L; Wang, Q; Li, W

Published Date

  • August 2010

Published In

Volume / Issue

  • 2 / 4

Start / End Page

  • 551 - 560

PubMed ID

  • 21318127

Pubmed Central ID

  • PMC3035388

Electronic International Standard Serial Number (EISSN)

  • 1750-192X

Digital Object Identifier (DOI)

  • 10.2217/epi.10.31

Language

  • eng

Conference Location

  • England