Mapping population-based structural connectomes.

Journal Article (Journal Article)

Advances in understanding the structural connectomes of human brain require improved approaches for the construction, comparison and integration of high-dimensional whole-brain tractography data from a large number of individuals. This article develops a population-based structural connectome (PSC) mapping framework to address these challenges. PSC simultaneously characterizes a large number of white matter bundles within and across different subjects by registering different subjects' brains based on coarse cortical parcellations, compressing the bundles of each connection, and extracting novel connection weights. A robust tractography algorithm and streamline post-processing techniques, including dilation of gray matter regions, streamline cutting, and outlier streamline removal are applied to improve the robustness of the extracted structural connectomes. The developed PSC framework can be used to reproducibly extract binary networks, weighted networks and streamline-based brain connectomes. We apply the PSC to Human Connectome Project data to illustrate its application in characterizing normal variations and heritability of structural connectomes in healthy subjects.

Full Text

Duke Authors

Cited Authors

  • Zhang, Z; Descoteaux, M; Zhang, J; Girard, G; Chamberland, M; Dunson, D; Srivastava, A; Zhu, H

Published Date

  • May 2018

Published In

Volume / Issue

  • 172 /

Start / End Page

  • 130 - 145

PubMed ID

  • 29355769

Pubmed Central ID

  • PMC5910206

Electronic International Standard Serial Number (EISSN)

  • 1095-9572

International Standard Serial Number (ISSN)

  • 1053-8119

Digital Object Identifier (DOI)

  • 10.1016/j.neuroimage.2017.12.064


  • eng