Hypertrophic cardiomyopathy: etiology, diagnosis, and treatment.


Journal Article (Review)

Hypertrophic cardiomyopathy (HCM) is a disease characterized by primary hypertrophy of the left (and sometimes right) ventricle. The clinical manifestations of the disease are dyspnea, angina, and a continuum encompassing lightheadedness, presyncope, syncope, and sudden death. Although HCM is often caused by an identifiable mutation in a gene coding for a sarcomeric protein and inherited in an autosomal-dominant pattern, many patients do not have any relatives in whom the disease is manifest. The prevalence of HCM is estimated to be 0.2%, with nearly 600,000 Americans affected. This limited exposure of clinicians to HCM understandably accounts for the uncertainty that prevails regarding this disease and its management.

Full Text

Duke Authors

Cited Authors

  • Ramaraj, R

Published Date

  • July 2008

Published In

Volume / Issue

  • 16 / 4

Start / End Page

  • 172 - 180

PubMed ID

  • 18562807

Pubmed Central ID

  • 18562807

Electronic International Standard Serial Number (EISSN)

  • 1538-4683

Digital Object Identifier (DOI)

  • 10.1097/CRD.0b013e318178e525


  • eng

Conference Location

  • United States