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18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.

Publication ,  Journal Article
Klinger, RY; James, OG; Borges-Neto, S; Bisanar, T; Li, Y-J; Qi, W; Berger, M; Terrando, N; Newman, MF; Doraiswamy, PM; Mathew, JP ...
Published in: Anesthesiology
April 2018

BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9). The association of 6-week amyloid deposition with cognitive dysfunction was assessed by multivariable regression, accounting for age, years of education, and baseline cognition. Differences between the surgical cohort with cognitive deficit and the Alzheimer's Disease Neuroimaging Initiative cohorts (normal and early/late mild cognitive impairment) was assessed, adjusting for age, education, and apolipoprotein E4 genotype. RESULTS: The authors found that 6-week abnormal global cortical amyloid deposition was not associated with cognitive dysfunction (13 of 37, 35%) at 6 weeks postoperatively (median standard uptake value ratio [interquartile range]: cognitive dysfunction 0.92 [0.89 to 1.07] vs. 0.98 [0.93 to 1.05]; P = 0.455). In post hoc analyses, global cortical amyloid was also not associated with cognitive dysfunction at 1 or 3 yr postoperatively. Amyloid deposition at 6 weeks in the surgical cohort was not different from that in normal Alzheimer's Disease Neuroimaging Initiative subjects, but increased over 1 yr in many areas at a rate greater than in controls. CONCLUSIONS: In this study, postoperative cognitive dysfunction was not associated with 6-week cortical amyloid deposition. The relationship between cognitive dysfunction and regional amyloid burden and the rate of postoperative amyloid deposition merit further investigation.

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Published In

Anesthesiology

DOI

EISSN

1528-1175

Publication Date

April 2018

Volume

128

Issue

4

Start / End Page

728 / 744

Location

United States

Related Subject Headings

  • Prospective Studies
  • Postoperative Complications
  • Positron-Emission Tomography
  • Middle Aged
  • Mental Status and Dementia Tests
  • Male
  • Humans
  • Fluorine Radioisotopes
  • Female
  • Ethylene Glycols
 

Citation

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Klinger, R. Y., James, O. G., Borges-Neto, S., Bisanar, T., Li, Y.-J., Qi, W., … Neurologic Outcomes Research Group (NORG), . (2018). 18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery. Anesthesiology, 128(4), 728–744. https://doi.org/10.1097/ALN.0000000000002103
Klinger, Rebecca Y., Olga G. James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, et al. “18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.Anesthesiology 128, no. 4 (April 2018): 728–44. https://doi.org/10.1097/ALN.0000000000002103.
Klinger RY, James OG, Borges-Neto S, Bisanar T, Li Y-J, Qi W, et al. 18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery. Anesthesiology. 2018 Apr;128(4):728–44.
Klinger, Rebecca Y., et al. “18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.Anesthesiology, vol. 128, no. 4, Apr. 2018, pp. 728–44. Pubmed, doi:10.1097/ALN.0000000000002103.
Klinger RY, James OG, Borges-Neto S, Bisanar T, Li Y-J, Qi W, Berger M, Terrando N, Newman MF, Doraiswamy PM, Mathew JP, Alzheimer’s Disease Neuroimaging Initiative (ADNI) Study Group, Neurologic Outcomes Research Group (NORG). 18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery. Anesthesiology. 2018 Apr;128(4):728–744.

Published In

Anesthesiology

DOI

EISSN

1528-1175

Publication Date

April 2018

Volume

128

Issue

4

Start / End Page

728 / 744

Location

United States

Related Subject Headings

  • Prospective Studies
  • Postoperative Complications
  • Positron-Emission Tomography
  • Middle Aged
  • Mental Status and Dementia Tests
  • Male
  • Humans
  • Fluorine Radioisotopes
  • Female
  • Ethylene Glycols