Fructose metabolism and metabolic disease.

Journal Article (Journal Article;Review)

Increased sugar consumption is increasingly considered to be a contributor to the worldwide epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of its unique metabolic properties, the fructose component of sugar may be particularly harmful. Diets high in fructose can rapidly produce all of the key features of the metabolic syndrome. Here we review the biology of fructose metabolism as well as potential mechanisms by which excessive fructose consumption may contribute to cardiometabolic disease.

Full Text

Duke Authors

Cited Authors

  • Hannou, SA; Haslam, DE; McKeown, NM; Herman, MA

Published Date

  • February 1, 2018

Published In

Volume / Issue

  • 128 / 2

Start / End Page

  • 545 - 555

PubMed ID

  • 29388924

Pubmed Central ID

  • PMC5785258

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI96702


  • eng

Conference Location

  • United States