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The potential role of complements in cocaine-induced thrombotic microangiopathy.

Publication ,  Journal Article
Dejman, A; Alavi, SN; Thomas, DB; Stefanovic, A; Asif, A; Nayer, A
Published in: Clin Kidney J
February 2018

Thrombotic microangiopathy (TMA) is a rare disorder characterized by microvascular injury and occlusion resulting in tissue ischemia and dysfunction. TMA occurs in a variety of settings including cocaine use. Although cocaine is widely used in the United States, cocaine-associated TMA is only rarely reported. Therefore, other factors may predispose cocaine users to the development of TMA. Emerging evidence indicates that cocaine activates complements. Therefore, complement activation may contribute to the development of cocaine-induced TMA. Here, we report a cocaine user who presented with renal failure. Renal biopsy demonstrated TMA. Laboratory tests revealed reduced serum complement C3 and normal complement C4 levels indicative of alternative complement activation. We postulate that complement activation is involved in the pathogenesis of cocaine-induced TMA.

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Published In

Clin Kidney J

DOI

ISSN

2048-8505

Publication Date

February 2018

Volume

11

Issue

1

Start / End Page

26 / 28

Location

England

Related Subject Headings

  • 3202 Clinical sciences
 

Citation

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Dejman, A., Alavi, S. N., Thomas, D. B., Stefanovic, A., Asif, A., & Nayer, A. (2018). The potential role of complements in cocaine-induced thrombotic microangiopathy. Clin Kidney J, 11(1), 26–28. https://doi.org/10.1093/ckj/sfx061
Dejman, Adriana, Seyed Navid Alavi, David B. Thomas, Alexandra Stefanovic, Arif Asif, and Ali Nayer. “The potential role of complements in cocaine-induced thrombotic microangiopathy.Clin Kidney J 11, no. 1 (February 2018): 26–28. https://doi.org/10.1093/ckj/sfx061.
Dejman A, Alavi SN, Thomas DB, Stefanovic A, Asif A, Nayer A. The potential role of complements in cocaine-induced thrombotic microangiopathy. Clin Kidney J. 2018 Feb;11(1):26–8.
Dejman, Adriana, et al. “The potential role of complements in cocaine-induced thrombotic microangiopathy.Clin Kidney J, vol. 11, no. 1, Feb. 2018, pp. 26–28. Pubmed, doi:10.1093/ckj/sfx061.
Dejman A, Alavi SN, Thomas DB, Stefanovic A, Asif A, Nayer A. The potential role of complements in cocaine-induced thrombotic microangiopathy. Clin Kidney J. 2018 Feb;11(1):26–28.

Published In

Clin Kidney J

DOI

ISSN

2048-8505

Publication Date

February 2018

Volume

11

Issue

1

Start / End Page

26 / 28

Location

England

Related Subject Headings

  • 3202 Clinical sciences