Epigenetic regulation of male fate commitment from an initially bipotential system.

Journal Article (Journal Article;Review)

A fundamental goal in biology is to understand how distinct cell types containing the same genetic information arise from a single stem cell throughout development. Sex determination is a key developmental process that requires a unidirectional commitment of an initially bipotential gonad towards either the male or female fate. This makes sex determination a unique model to study cell fate commitment and differentiation in vivo. We have focused this review on the accumulating evidence that epigenetic mechanisms contribute to the bipotential state of the fetal gonad and to the regulation of chromatin accessibility during and immediately downstream of the primary sex-determining switch that establishes the male fate.

Full Text

Duke Authors

Cited Authors

  • Garcia-Moreno, SA; Plebanek, MP; Capel, B

Published Date

  • June 15, 2018

Published In

Volume / Issue

  • 468 /

Start / End Page

  • 19 - 30

PubMed ID

  • 29410272

Pubmed Central ID

  • PMC6084468

Electronic International Standard Serial Number (EISSN)

  • 1872-8057

Digital Object Identifier (DOI)

  • 10.1016/j.mce.2018.01.009


  • eng

Conference Location

  • Ireland