Extracellular matrix-based intracortical microelectrodes: Toward a microfabricated neural interface based on natural materials.

Journal Article (Journal Article)

Extracellular matrix (ECM)-based implantable neural electrodes (NEs) were achieved using a microfabrication strategy on natural-substrate-based organic materials. The ECM-based design minimized the introduction of non-natural products into the brain. Further, it rendered the implants sufficiently rigid for penetration into the target brain region and allowed them subsequently to soften to match the elastic modulus of brain tissue upon exposure to physiological conditions, thereby reducing inflammatory strain fields in the tissue. Preliminary studies suggested that ECM-NEs produce a reduced inflammatory response compared with inorganic rigid and flexible approaches. In vivo intracortical recordings from the rat motor cortex illustrate one mode of use for these ECM-NEs.

Full Text

Duke Authors

Cited Authors

  • Shen, W; Karumbaiah, L; Liu, X; Saxena, T; Chen, S; Patkar, R; Bellamkonda, RV; Allen, MG

Published Date

  • January 2015

Published In

Volume / Issue

  • 1 / 1

Start / End Page

  • 15010 -

PubMed ID

  • 30498620

Pubmed Central ID

  • PMC6258041

Electronic International Standard Serial Number (EISSN)

  • 2055-7434

International Standard Serial Number (ISSN)

  • 2096-1030

Digital Object Identifier (DOI)

  • 10.1038/micronano.2015.10

Language

  • eng