Neighborhoods, sleep quality, and cognitive decline: Does where you live and how well you sleep matter?

Journal Article (Journal Article)

INTRODUCTION: We evaluated the association between neighborhood socioeconomic status (NSES) and sleep quality on cognitive decline in the Health and Retirement Study. METHODS: Health and Retirement Study participants (n = 8090), aged 65+ with DNA and multiple biennial cognitive observations (abbreviated Telephone Interview for Cognitive Status), were included. Participants were grouped into quartiles of NSES and sleep quality scores. We adjusted for apolipoprotein E ε4, demographic, and cardiovascular risk factors. Random effects modeling evaluated cognitive change over time. RESULTS: NSES and sleep were significantly associated with cognitive decline, and there was a significant interaction between them (P = .02). Significant differences between high/low NSES and high/low sleep quality (P < .0001) were found. DISCUSSION: Sleep and NSES were associated with cognitive decline; the association between sleep and cognition appeared stronger among those with low NSES. The association between low NSES, poor sleep quality, and cognitive decline was roughly equivalent to the association between apolipoprotein E ε4 and cognitive decline.

Full Text

Duke Authors

Cited Authors

  • Hunter, JC; Handing, EP; Casanova, R; Kuchibhatla, M; Lutz, MW; Saldana, S; Plassman, BL; Hayden, KM

Published Date

  • April 2018

Published In

Volume / Issue

  • 14 / 4

Start / End Page

  • 454 - 461

PubMed ID

  • 29396109

Pubmed Central ID

  • PMC5899662

Electronic International Standard Serial Number (EISSN)

  • 1552-5279

Digital Object Identifier (DOI)

  • 10.1016/j.jalz.2017.10.007


  • eng

Conference Location

  • United States