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Models of retinal diseases and their applicability in drug discovery.

Publication ,  Journal Article
Malek, G; Busik, J; Grant, MB; Choudhary, M
Published in: Expert Opin Drug Discov
April 2018

The impact of vision debilitating diseases is a global public health concern, which will continue until effective preventative and management protocols are developed. Two retinal diseases responsible for the majority of vision loss in the working age adults and elderly populations are diabetic retinopathy (DR) and age-related macular degeneration (AMD), respectively. Model systems, which recapitulate aspects of human pathology, are valid experimental modalities that have contributed to the identification of signaling pathways involved in disease development and consequently potential therapies. Areas covered: The pathology of DR and AMD, which serve as the basis for designing appropriate models of disease, is discussed. The authors also review in vitro and in vivo models of DR and AMD and evaluate the utility of these models in exploratory and pre-clinical studies. Expert opinion: The complex nature of non-Mendelian diseases such as DR and AMD has made identification of effective therapeutic treatments challenging. However, the authors believe that while in vivo models are often criticized for not being a 'perfect' recapitulation of disease, they have been valuable experimentally when used with consideration of the strengths and limitations of the experimental model selected and have a place in the drug discovery process.

Duke Scholars

Published In

Expert Opin Drug Discov

DOI

EISSN

1746-045X

Publication Date

April 2018

Volume

13

Issue

4

Start / End Page

359 / 377

Location

England

Related Subject Headings

  • Pharmacology & Pharmacy
  • Macular Degeneration
  • Humans
  • Drug Discovery
  • Drug Design
  • Disease Models, Animal
  • Diabetic Retinopathy
  • Animals
  • Aged
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Malek, G., Busik, J., Grant, M. B., & Choudhary, M. (2018). Models of retinal diseases and their applicability in drug discovery. Expert Opin Drug Discov, 13(4), 359–377. https://doi.org/10.1080/17460441.2018.1430136
Malek, Goldis, Julia Busik, Maria B. Grant, and Mayur Choudhary. “Models of retinal diseases and their applicability in drug discovery.Expert Opin Drug Discov 13, no. 4 (April 2018): 359–77. https://doi.org/10.1080/17460441.2018.1430136.
Malek G, Busik J, Grant MB, Choudhary M. Models of retinal diseases and their applicability in drug discovery. Expert Opin Drug Discov. 2018 Apr;13(4):359–77.
Malek, Goldis, et al. “Models of retinal diseases and their applicability in drug discovery.Expert Opin Drug Discov, vol. 13, no. 4, Apr. 2018, pp. 359–77. Pubmed, doi:10.1080/17460441.2018.1430136.
Malek G, Busik J, Grant MB, Choudhary M. Models of retinal diseases and their applicability in drug discovery. Expert Opin Drug Discov. 2018 Apr;13(4):359–377.

Published In

Expert Opin Drug Discov

DOI

EISSN

1746-045X

Publication Date

April 2018

Volume

13

Issue

4

Start / End Page

359 / 377

Location

England

Related Subject Headings

  • Pharmacology & Pharmacy
  • Macular Degeneration
  • Humans
  • Drug Discovery
  • Drug Design
  • Disease Models, Animal
  • Diabetic Retinopathy
  • Animals
  • Aged
  • Adult