Polygenic loading for major depression is associated with specific medical comorbidity.

Published online

Journal Article

Major depressive disorder frequently co-occurs with medical disorders, raising the possibility of shared genetic liability. Recent identification of 15 novel genetic loci associated with depression allows direct investigation of this question. In cohorts of individuals participating in biobanks at two academic medical centers, we calculated polygenic loading for risk loci reported to be associated with depression. We then examined the association between such loading and 50 groups of clinical diagnoses, or topics, drawn from these patients' electronic health records, determined using a novel application of latent Dirichilet allocation. Three topics showed experiment-wide association with the depression liability score; these included diagnostic groups representing greater prevalence of mood and anxiety disorders, greater prevalence of cardiac ischemia, and a decreased prevalence of heart failure. The latter two associations persisted even among individuals with no mood disorder diagnosis. This application of a novel method for grouping related diagnoses in biobanks indicate shared genetic risk for depression and cardiac disease, with a pattern suggesting greater ischemic risk and diminished heart failure risk.

Full Text

Duke Authors

Cited Authors

  • McCoy, TH; Castro, VM; Snapper, L; Hart, K; Januzzi, JL; Huffman, JC; Perlis, RH

Published Date

  • September 19, 2017

Published In

Volume / Issue

  • 7 / 9

Start / End Page

  • e1238 -

PubMed ID

  • 28926002

Pubmed Central ID

  • 28926002

Electronic International Standard Serial Number (EISSN)

  • 2158-3188

Digital Object Identifier (DOI)

  • 10.1038/tp.2017.201


  • eng

Conference Location

  • United States