Skip to main content
Journal cover image

Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem.

Publication ,  Journal Article
Rogerson, SJ; Desai, M; Mayor, A; Sicuri, E; Taylor, SM; van Eijk, AM
Published in: Lancet Infect Dis
April 2018

Over the past 10 years, knowledge of the burden, economic costs, and consequences of malaria in pregnancy has improved, and the prevalence of malaria caused by Plasmodium falciparum has declined substantially in some geographical areas. In particular, studies outside of Africa have increased the evidence base of Plasmodium vivax in pregnancy. Rapid diagnostic tests have been poor at detecting malaria in pregnant women, while PCR has shown a high prevalence of low density infection, the clinical importance of which is unknown. Erythrocytes infected with P falciparum that express the surface protein VAR2CSA accumulate in the placenta, and VAR2CSA is an important target of protective immunity. Clinical trials for a VAR2CSA vaccine are ongoing, but sequence variation needs to be carefully studied. Health system and household costs still limit access to prevention and treatment services. Within the context of malaria elimination, pregnant women could be used to monitor malaria transmission. This Series paper summarises recent progress and highlights unresolved issues related to the burden of malaria in pregnancy.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Lancet Infect Dis

DOI

EISSN

1474-4457

Publication Date

April 2018

Volume

18

Issue

4

Start / End Page

e107 / e118

Location

United States

Related Subject Headings

  • Prevalence
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Microbiology
  • Malaria, Vivax
  • Malaria, Falciparum
  • Humans
  • Health Care Costs
  • Female
  • Cost of Illness
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rogerson, S. J., Desai, M., Mayor, A., Sicuri, E., Taylor, S. M., & van Eijk, A. M. (2018). Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem. Lancet Infect Dis, 18(4), e107–e118. https://doi.org/10.1016/S1473-3099(18)30066-5
Rogerson, Stephen J., Meghna Desai, Alfredo Mayor, Elisa Sicuri, Steve M. Taylor, and Anna M. van Eijk. “Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem.Lancet Infect Dis 18, no. 4 (April 2018): e107–18. https://doi.org/10.1016/S1473-3099(18)30066-5.
Rogerson SJ, Desai M, Mayor A, Sicuri E, Taylor SM, van Eijk AM. Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem. Lancet Infect Dis. 2018 Apr;18(4):e107–18.
Rogerson, Stephen J., et al. “Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem.Lancet Infect Dis, vol. 18, no. 4, Apr. 2018, pp. e107–18. Pubmed, doi:10.1016/S1473-3099(18)30066-5.
Rogerson SJ, Desai M, Mayor A, Sicuri E, Taylor SM, van Eijk AM. Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem. Lancet Infect Dis. 2018 Apr;18(4):e107–e118.
Journal cover image

Published In

Lancet Infect Dis

DOI

EISSN

1474-4457

Publication Date

April 2018

Volume

18

Issue

4

Start / End Page

e107 / e118

Location

United States

Related Subject Headings

  • Prevalence
  • Pregnancy Complications, Infectious
  • Pregnancy
  • Microbiology
  • Malaria, Vivax
  • Malaria, Falciparum
  • Humans
  • Health Care Costs
  • Female
  • Cost of Illness