Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case-control study.

Published

Journal Article

Introduction:Persons living with HIV (PLWH) are at higher risk for cardiovascular disease (CVD) events than uninfected persons. Current risk-stratification methods to define PLWH at highest risk for CVD events are lacking. Methods:Using tandem flow injection mass spectrometry, we quantified plasma levels of 60 metabolites in 24 matched pairs of PLWH [1:1 with and without known coronary artery disease (CAD)]. Metabolite levels were reduced to interpretable factors using principal components analysis. Results:Factors derived from short-chain dicarboxylacylcarnitines (SCDA) (p = 0.08) and glutamine/valine (p = 0.003) were elevated in CAD cases compared to controls. Conclusion:SCDAs and glutamine/valine may be valuable markers of cardiovascular risk among persons living with HIV in the future, pending validation in larger cohorts.

Full Text

Duke Authors

Cited Authors

  • Okeke, NL; Craig, DM; Muehlbauer, MJ; Ilkayeva, O; Clement, ME; Naggie, S; Shah, SH

Published Date

  • March 2018

Published In

Volume / Issue

  • 14 / 3

PubMed ID

  • 30760970

Pubmed Central ID

  • 30760970

Electronic International Standard Serial Number (EISSN)

  • 1573-3890

International Standard Serial Number (ISSN)

  • 1573-3882

Digital Object Identifier (DOI)

  • 10.1007/s11306-018-1318-z

Language

  • eng