The effect of corticosteroids, dapsone and gold upon plasminogen activator synthesis and secretion by human epidermal cells cultured with pemphigus antibody.


Journal Article

Human epidermal cells were cultured with pemphigus antibody in the presence of hydrocortisone, methylprednisolone sodium succinate, dapsone and gold. Hydrocortisone and methylprednisolone reduced the production of the enzyme plasminogen activator but dapsone and gold had no effect. These results support the hypothesis that corticosteroids have dual effects on pemphigus through inhibition of plasminogen activator production by epidermal cells and suppression of pemphigus antibody production by B lymphocytes.

Full Text

Duke Authors

Cited Authors

  • Hashimoto, K; Singer, K; Lazarus, GS

Published Date

  • March 1, 1984

Published In

Volume / Issue

  • 110 / 3

Start / End Page

  • 293 - 297

PubMed ID

  • 6421306

Pubmed Central ID

  • 6421306

International Standard Serial Number (ISSN)

  • 0007-0963

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2133.1984.tb04634.x


  • eng

Conference Location

  • England