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The effect of corticosteroids, dapsone and gold upon plasminogen activator synthesis and secretion by human epidermal cells cultured with pemphigus antibody.

Publication ,  Journal Article
Hashimoto, K; Singer, K; Lazarus, GS
Published in: Br J Dermatol
March 1984

Human epidermal cells were cultured with pemphigus antibody in the presence of hydrocortisone, methylprednisolone sodium succinate, dapsone and gold. Hydrocortisone and methylprednisolone reduced the production of the enzyme plasminogen activator but dapsone and gold had no effect. These results support the hypothesis that corticosteroids have dual effects on pemphigus through inhibition of plasminogen activator production by epidermal cells and suppression of pemphigus antibody production by B lymphocytes.

Duke Scholars

Published In

Br J Dermatol

DOI

ISSN

0007-0963

Publication Date

March 1984

Volume

110

Issue

3

Start / End Page

293 / 297

Location

England

Related Subject Headings

  • Time Factors
  • Plasminogen Activators
  • Pemphigus
  • Methylprednisolone Hemisuccinate
  • Infant, Newborn
  • Hydrocortisone
  • Humans
  • Gold Sodium Thiomalate
  • Epidermis
  • Dermatology & Venereal Diseases
 

Citation

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Hashimoto, K., Singer, K., & Lazarus, G. S. (1984). The effect of corticosteroids, dapsone and gold upon plasminogen activator synthesis and secretion by human epidermal cells cultured with pemphigus antibody. Br J Dermatol, 110(3), 293–297. https://doi.org/10.1111/j.1365-2133.1984.tb04634.x
Hashimoto, K., K. Singer, and G. S. Lazarus. “The effect of corticosteroids, dapsone and gold upon plasminogen activator synthesis and secretion by human epidermal cells cultured with pemphigus antibody.Br J Dermatol 110, no. 3 (March 1984): 293–97. https://doi.org/10.1111/j.1365-2133.1984.tb04634.x.
Hashimoto, K., et al. “The effect of corticosteroids, dapsone and gold upon plasminogen activator synthesis and secretion by human epidermal cells cultured with pemphigus antibody.Br J Dermatol, vol. 110, no. 3, Mar. 1984, pp. 293–97. Pubmed, doi:10.1111/j.1365-2133.1984.tb04634.x.
Journal cover image

Published In

Br J Dermatol

DOI

ISSN

0007-0963

Publication Date

March 1984

Volume

110

Issue

3

Start / End Page

293 / 297

Location

England

Related Subject Headings

  • Time Factors
  • Plasminogen Activators
  • Pemphigus
  • Methylprednisolone Hemisuccinate
  • Infant, Newborn
  • Hydrocortisone
  • Humans
  • Gold Sodium Thiomalate
  • Epidermis
  • Dermatology & Venereal Diseases