Cutaneous polyarteritis nodosa. Report of a case associated with Crohn's disease.

Journal Article (Journal Article)

A patient had cutaneous polyarteritis nodosa associated with Crohn's disease. Immunopathologic studies disclosed evidence of circulating immune complexes as measured by C1q binding. Immunofluorescent microscopy of lesional skin showed C3 and fibrin deposition. Histamine injection of normal skin and subsequent biopsy specimens and immunofluorescent microscopy showed immune deposits. The patient was treated with cyclophosphamide and prednisone with a good clinical response, but within two years, histiocytic lymphoma developed. There is an association of cutaneous polyarteritis and Crohn's disease, and also, immunosuppressive therapy plays a role in the development of histiocytic lymphoma.

Full Text

Duke Authors

Cited Authors

  • Goslen, JB; Graham, W; Lazarus, GS

Published Date

  • April 1, 1983

Published In

Volume / Issue

  • 119 / 4

Start / End Page

  • 326 - 329

PubMed ID

  • 6132589

International Standard Serial Number (ISSN)

  • 0003-987X

Digital Object Identifier (DOI)

  • 10.1001/archderm.119.4.326


  • eng

Conference Location

  • United States