Production and secretion of proteolytic enzymes by normal and neoplastic cells.

Journal Article (Journal Article)

A possible mechanism for tumor cell invasion of normal tissue might be secretion of proteolytic enzymes. This study compares and contrasts production and secretion of proteinases by cell cultures of normal and chemically transformed mouse epithelial cells. Lysates of normal and neoplastic cells contain similar amounts of neutral proteinase, cathepsin D and plasminogen activator. Neither collagenase nor elastase could be identified in lysates of, or serum-free culture medium bathing, normal or neoplastic cells. Neoplastic cells secrete ten times more plasminogen activator than normal cells. Our data support the hypothesis that plasminogen activator produced by neoplastic cells could fuction to activate latent proteolytic enzymes secreted by connective tissue cells which might result in spread of neoplastic cells into normal tissue.

Full Text

Duke Authors

Cited Authors

  • Boyd, JB; Farb, RM; Yost, FJ; Georgiade, N; Lazarus, GS

Published Date

  • 1979

Published In

Volume / Issue

  • 11 / 3

Start / End Page

  • 275 - 282

PubMed ID

  • 459522

International Standard Serial Number (ISSN)

  • 0022-4790

Digital Object Identifier (DOI)

  • 10.1002/jso.2930110314


  • eng

Conference Location

  • United States