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Penicillamine-induced pemphigus. Immunoglobulin from this patient induces plasminogen activator synthesis by human epidermal cells in culture: mechanism for acantholysis in pemphigus.

Publication ,  Journal Article
Hashimoto, K; Singer, K; Lazarus, GS
Published in: Arch Dermatol
June 1984

The incubation of cultured epidermal cells with IgG obtained from a 56-year-old man with penicillamine-induced pemphigus resulted in an increase in extracellular and intracellular plasminogen activator. This suggests that penicillamine-induced pemphigus and spontaneously occurring pemphigus share common pathophysiologic processes in the induction of blister formation.

Duke Scholars

Published In

Arch Dermatol

DOI

ISSN

0003-987X

Publication Date

June 1984

Volume

120

Issue

6

Start / End Page

762 / 764

Location

United States

Related Subject Headings

  • Plasminogen Activators
  • Penicillamine
  • Pemphigus
  • Middle Aged
  • Male
  • Immunoglobulin G
  • Humans
  • Epidermis
  • Dermatology & Venereal Diseases
  • Cells, Cultured
 

Citation

Published In

Arch Dermatol

DOI

ISSN

0003-987X

Publication Date

June 1984

Volume

120

Issue

6

Start / End Page

762 / 764

Location

United States

Related Subject Headings

  • Plasminogen Activators
  • Penicillamine
  • Pemphigus
  • Middle Aged
  • Male
  • Immunoglobulin G
  • Humans
  • Epidermis
  • Dermatology & Venereal Diseases
  • Cells, Cultured