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Invasiveness is associated with metastasis and decreased survival in hemangiopericytoma of the central nervous system.

Publication ,  Journal Article
Kinslow, CJ; Rajpara, RS; Wu, C-C; Bruce, SS; Canoll, PD; Wang, S-H; Sonabend, AM; Sheth, SA; McKhann, GM; Sisti, MB; Bruce, JN; Wang, TJC
Published in: J Neurooncol
June 2017

Meningeal hemangiopericytoma (m-HPC) is a rare tumor of the central nervous system (CNS), which is distinguished clinically from meningioma by its tendency to recur and metastasize. The histological classification and grading scheme for m-HPC is still evolving and few studies have identified tumor features that are associated with metastasis. All patients at our institution with m-HPC were assessed for patient, tumor, and treatment characteristics associated with survival, recurrence, and metastasis. New findings were validated using the SEER database. Twenty-seven patients were identified in our institutional records with m-HPC with a median follow-up time of 85 months. Invasiveness was the strongest predictor of decreased overall survival (OS) and decreased metastasis-free survival (MFS) (p = 0.004 and 0.001). On subgroup analysis, bone invasion trended towards decreased OS (p = 0.056). Bone invasion and soft tissue invasion were significantly associated with decreased MFS (p = 0.001 and 0.012). An additional 315 patients with m-HPC were identified in the SEER database that had information on tumor invasion and 263 with information on distant metastasis. Invasion was significantly associated with decreased survival (HR = 5.769, p = 0.007) and metastasis (OR 134, p = 0.000) in the SEER data. In this study, the authors identified a previously unreported tumor characteristic, invasiveness, as the strongest factor associated with decreased survival and metastasis. The association of invasion with decreased survival and metastasis was confirmed in a separate, larger, publicly available database. Invasion may be a useful parameter in the histological grading and clinical management of hemangiopericytoma of the CNS.

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Published In

J Neurooncol

DOI

EISSN

1573-7373

Publication Date

June 2017

Volume

133

Issue

2

Start / End Page

409 / 417

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Proportional Hazards Models
  • Oncology & Carcinogenesis
  • Neoplasm Invasiveness
  • Middle Aged
  • Male
  • Kaplan-Meier Estimate
  • Humans
  • Hemangiopericytoma
  • Follow-Up Studies
 

Citation

APA
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MLA
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Kinslow, C. J., Rajpara, R. S., Wu, C.-C., Bruce, S. S., Canoll, P. D., Wang, S.-H., … Wang, T. J. C. (2017). Invasiveness is associated with metastasis and decreased survival in hemangiopericytoma of the central nervous system. J Neurooncol, 133(2), 409–417. https://doi.org/10.1007/s11060-017-2450-8
Kinslow, Connor J., Raj S. Rajpara, Cheng-Chia Wu, Samuel S. Bruce, Peter D. Canoll, Shih-Hsiu Wang, Adam M. Sonabend, et al. “Invasiveness is associated with metastasis and decreased survival in hemangiopericytoma of the central nervous system.J Neurooncol 133, no. 2 (June 2017): 409–17. https://doi.org/10.1007/s11060-017-2450-8.
Kinslow CJ, Rajpara RS, Wu C-C, Bruce SS, Canoll PD, Wang S-H, et al. Invasiveness is associated with metastasis and decreased survival in hemangiopericytoma of the central nervous system. J Neurooncol. 2017 Jun;133(2):409–17.
Kinslow, Connor J., et al. “Invasiveness is associated with metastasis and decreased survival in hemangiopericytoma of the central nervous system.J Neurooncol, vol. 133, no. 2, June 2017, pp. 409–17. Pubmed, doi:10.1007/s11060-017-2450-8.
Kinslow CJ, Rajpara RS, Wu C-C, Bruce SS, Canoll PD, Wang S-H, Sonabend AM, Sheth SA, McKhann GM, Sisti MB, Bruce JN, Wang TJC. Invasiveness is associated with metastasis and decreased survival in hemangiopericytoma of the central nervous system. J Neurooncol. 2017 Jun;133(2):409–417.
Journal cover image

Published In

J Neurooncol

DOI

EISSN

1573-7373

Publication Date

June 2017

Volume

133

Issue

2

Start / End Page

409 / 417

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Proportional Hazards Models
  • Oncology & Carcinogenesis
  • Neoplasm Invasiveness
  • Middle Aged
  • Male
  • Kaplan-Meier Estimate
  • Humans
  • Hemangiopericytoma
  • Follow-Up Studies