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Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM).

Publication ,  Journal Article
Sai, KKS; Fan, J; Tu, Z; Zerkel, P; Mach, RH; Kharasch, ED
Published in: Appl Radiat Isot
September 2014

Long-acting opioid agonists methadone and l-α-acetylmethadol (LAAM) prevent withdrawal in opioid-dependent persons. Attempts to synthesize [(11)C]-methadone for PET evaluation of brain disposition were unsuccessful. Owing, however, to structural and pharmacologic similarities, we aimed to develop [(11)C]LAAM as a PET ligand to probe the brain exposure of long-lasting opioids in humans. This manuscript describes [(11)C]LAAM synthesis and its biodistribution in mice. The radiochemical synthetic strategy afforded high radiochemical yield, purity and specific activity, thereby making the synthesis adaptable to automated modules.

Duke Scholars

Published In

Appl Radiat Isot

DOI

EISSN

1872-9800

Publication Date

September 2014

Volume

91

Start / End Page

135 / 140

Location

England

Related Subject Headings

  • Tissue Distribution
  • Radiopharmaceuticals
  • Positron-Emission Tomography
  • Nuclear Medicine & Medical Imaging
  • Mice
  • Methadyl Acetate
  • Male
  • Carbon Radioisotopes
  • Brain
  • Animals
 

Citation

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ICMJE
MLA
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Sai, K. K. S., Fan, J., Tu, Z., Zerkel, P., Mach, R. H., & Kharasch, E. D. (2014). Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM). Appl Radiat Isot, 91, 135–140. https://doi.org/10.1016/j.apradiso.2014.05.019
Sai, Kiran Kumar Solingapuram, Jinda Fan, Zhude Tu, Patrick Zerkel, Robert H. Mach, and Evan D. Kharasch. “Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM).Appl Radiat Isot 91 (September 2014): 135–40. https://doi.org/10.1016/j.apradiso.2014.05.019.
Sai KKS, Fan J, Tu Z, Zerkel P, Mach RH, Kharasch ED. Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM). Appl Radiat Isot. 2014 Sep;91:135–40.
Sai, Kiran Kumar Solingapuram, et al. “Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM).Appl Radiat Isot, vol. 91, Sept. 2014, pp. 135–40. Pubmed, doi:10.1016/j.apradiso.2014.05.019.
Sai KKS, Fan J, Tu Z, Zerkel P, Mach RH, Kharasch ED. Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM). Appl Radiat Isot. 2014 Sep;91:135–140.
Journal cover image

Published In

Appl Radiat Isot

DOI

EISSN

1872-9800

Publication Date

September 2014

Volume

91

Start / End Page

135 / 140

Location

England

Related Subject Headings

  • Tissue Distribution
  • Radiopharmaceuticals
  • Positron-Emission Tomography
  • Nuclear Medicine & Medical Imaging
  • Mice
  • Methadyl Acetate
  • Male
  • Carbon Radioisotopes
  • Brain
  • Animals