Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM).
Publication
, Journal Article
Sai, KKS; Fan, J; Tu, Z; Zerkel, P; Mach, RH; Kharasch, ED
Published in: Appl Radiat Isot
September 2014
Long-acting opioid agonists methadone and l-α-acetylmethadol (LAAM) prevent withdrawal in opioid-dependent persons. Attempts to synthesize [(11)C]-methadone for PET evaluation of brain disposition were unsuccessful. Owing, however, to structural and pharmacologic similarities, we aimed to develop [(11)C]LAAM as a PET ligand to probe the brain exposure of long-lasting opioids in humans. This manuscript describes [(11)C]LAAM synthesis and its biodistribution in mice. The radiochemical synthetic strategy afforded high radiochemical yield, purity and specific activity, thereby making the synthesis adaptable to automated modules.
Duke Scholars
Published In
Appl Radiat Isot
DOI
EISSN
1872-9800
Publication Date
September 2014
Volume
91
Start / End Page
135 / 140
Location
England
Related Subject Headings
- Tissue Distribution
- Radiopharmaceuticals
- Positron-Emission Tomography
- Nuclear Medicine & Medical Imaging
- Mice
- Methadyl Acetate
- Male
- Carbon Radioisotopes
- Brain
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Sai, K. K. S., Fan, J., Tu, Z., Zerkel, P., Mach, R. H., & Kharasch, E. D. (2014). Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM). Appl Radiat Isot, 91, 135–140. https://doi.org/10.1016/j.apradiso.2014.05.019
Sai, Kiran Kumar Solingapuram, Jinda Fan, Zhude Tu, Patrick Zerkel, Robert H. Mach, and Evan D. Kharasch. “Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM).” Appl Radiat Isot 91 (September 2014): 135–40. https://doi.org/10.1016/j.apradiso.2014.05.019.
Sai KKS, Fan J, Tu Z, Zerkel P, Mach RH, Kharasch ED. Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM). Appl Radiat Isot. 2014 Sep;91:135–40.
Sai, Kiran Kumar Solingapuram, et al. “Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM).” Appl Radiat Isot, vol. 91, Sept. 2014, pp. 135–40. Pubmed, doi:10.1016/j.apradiso.2014.05.019.
Sai KKS, Fan J, Tu Z, Zerkel P, Mach RH, Kharasch ED. Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM). Appl Radiat Isot. 2014 Sep;91:135–140.
Published In
Appl Radiat Isot
DOI
EISSN
1872-9800
Publication Date
September 2014
Volume
91
Start / End Page
135 / 140
Location
England
Related Subject Headings
- Tissue Distribution
- Radiopharmaceuticals
- Positron-Emission Tomography
- Nuclear Medicine & Medical Imaging
- Mice
- Methadyl Acetate
- Male
- Carbon Radioisotopes
- Brain
- Animals