Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM).
Journal Article
Long-acting opioid agonists methadone and l-α-acetylmethadol (LAAM) prevent withdrawal in opioid-dependent persons. Attempts to synthesize [(11)C]-methadone for PET evaluation of brain disposition were unsuccessful. Owing, however, to structural and pharmacologic similarities, we aimed to develop [(11)C]LAAM as a PET ligand to probe the brain exposure of long-lasting opioids in humans. This manuscript describes [(11)C]LAAM synthesis and its biodistribution in mice. The radiochemical synthetic strategy afforded high radiochemical yield, purity and specific activity, thereby making the synthesis adaptable to automated modules.
Full Text
Duke Authors
Cited Authors
- Sai, KKS; Fan, J; Tu, Z; Zerkel, P; Mach, RH; Kharasch, ED
Published Date
- September 2014
Published In
Volume / Issue
- 91 /
Start / End Page
- 135 - 140
PubMed ID
- 24935116
Pubmed Central ID
- 24935116
Electronic International Standard Serial Number (EISSN)
- 1872-9800
Digital Object Identifier (DOI)
- 10.1016/j.apradiso.2014.05.019
Language
- eng
Conference Location
- England