Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.
Publication
, Journal Article
Crews, KR; Gaedigk, A; Dunnenberger, HM; Leeder, JS; Klein, TE; Caudle, KE; Haidar, CE; Shen, DD; Callaghan, JT; Sadhasivam, S; Prows, CA ...
Published in: Clin Pharmacol Ther
April 2014
Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome P450 2D6 (CYP2D6); hence, the efficacy and safety of codeine are governed by CYP2D6 activity. Polymorphisms are a major cause of CYP2D6 variability. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for codeine based on CYP2D6 genotype. This document is an update to the 2012 Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for CYP2D6 genotype and codeine therapy.
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Published In
Clin Pharmacol Ther
DOI
EISSN
1532-6535
Publication Date
April 2014
Volume
95
Issue
4
Start / End Page
376 / 382
Location
United States
Related Subject Headings
- Polymorphism, Genetic
- Pharmacology & Pharmacy
- Pharmacogenetics
- Morphine
- Humans
- Genotype
- Genetic Testing
- Cytochrome P-450 CYP2D6
- Codeine
- Analgesics, Opioid
Citation
APA
Chicago
ICMJE
MLA
NLM
Crews, K. R., Gaedigk, A., Dunnenberger, H. M., Leeder, J. S., Klein, T. E., Caudle, K. E., … Clinical Pharmacogenetics Implementation Consortium, . (2014). Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther, 95(4), 376–382. https://doi.org/10.1038/clpt.2013.254
Crews, K. R., A. Gaedigk, H. M. Dunnenberger, J. S. Leeder, T. E. Klein, K. E. Caudle, C. E. Haidar, et al. “Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.” Clin Pharmacol Ther 95, no. 4 (April 2014): 376–82. https://doi.org/10.1038/clpt.2013.254.
Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, et al. Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376–82.
Crews, K. R., et al. “Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.” Clin Pharmacol Ther, vol. 95, no. 4, Apr. 2014, pp. 376–82. Pubmed, doi:10.1038/clpt.2013.254.
Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC, Clinical Pharmacogenetics Implementation Consortium. Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376–382.
Published In
Clin Pharmacol Ther
DOI
EISSN
1532-6535
Publication Date
April 2014
Volume
95
Issue
4
Start / End Page
376 / 382
Location
United States
Related Subject Headings
- Polymorphism, Genetic
- Pharmacology & Pharmacy
- Pharmacogenetics
- Morphine
- Humans
- Genotype
- Genetic Testing
- Cytochrome P-450 CYP2D6
- Codeine
- Analgesics, Opioid