Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.

Journal Article (Journal Article;Review)

Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome P450 2D6 (CYP2D6); hence, the efficacy and safety of codeine are governed by CYP2D6 activity. Polymorphisms are a major cause of CYP2D6 variability. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for codeine based on CYP2D6 genotype. This document is an update to the 2012 Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for CYP2D6 genotype and codeine therapy.

Full Text

Duke Authors

Cited Authors

  • Crews, KR; Gaedigk, A; Dunnenberger, HM; Leeder, JS; Klein, TE; Caudle, KE; Haidar, CE; Shen, DD; Callaghan, JT; Sadhasivam, S; Prows, CA; Kharasch, ED; Skaar, TC; Clinical Pharmacogenetics Implementation Consortium,

Published Date

  • April 2014

Published In

Volume / Issue

  • 95 / 4

Start / End Page

  • 376 - 382

PubMed ID

  • 24458010

Pubmed Central ID

  • PMC3975212

Electronic International Standard Serial Number (EISSN)

  • 1532-6535

Digital Object Identifier (DOI)

  • 10.1038/clpt.2013.254

Language

  • eng

Conference Location

  • United States