Bioplasmonic paper as a platform for detection of kidney cancer biomarkers.
We demonstrate that a common laboratory filter paper uniformly adsorbed with biofunctionalized plasmonic nanostructures can serve as a highly sensitive transduction platform for rapid detection of trace bioanalytes in physiological fluids. In particular, we demonstrate that bioplasmonic paper enables rapid urinalysis for the detection of kidney cancer biomarkers in artificial urine down to a concentration of 10 ng/mL. Compared to conventional rigid substrates, bioplasmonic paper offers numerous advantages such as high specific surface area (resulting in large dynamic range), excellent wicking properties (naturally microfluidic), mechanical flexibility, compatibility with conventional printing approaches (enabling multiplexed detection and multimarker biochips), and significant cost reduction.
Duke Scholars
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Related Subject Headings
- Urinalysis
- Surface Plasmon Resonance
- Paper
- Nanotubes
- Limit of Detection
- Kidney Neoplasms
- Immunoglobulin G
- Humans
- Gold
- Filtration
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Urinalysis
- Surface Plasmon Resonance
- Paper
- Nanotubes
- Limit of Detection
- Kidney Neoplasms
- Immunoglobulin G
- Humans
- Gold
- Filtration