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Bioplasmonic paper as a platform for detection of kidney cancer biomarkers.

Publication ,  Journal Article
Tian, L; Morrissey, JJ; Kattumenu, R; Gandra, N; Kharasch, ED; Singamaneni, S
Published in: Anal Chem
November 20, 2012

We demonstrate that a common laboratory filter paper uniformly adsorbed with biofunctionalized plasmonic nanostructures can serve as a highly sensitive transduction platform for rapid detection of trace bioanalytes in physiological fluids. In particular, we demonstrate that bioplasmonic paper enables rapid urinalysis for the detection of kidney cancer biomarkers in artificial urine down to a concentration of 10 ng/mL. Compared to conventional rigid substrates, bioplasmonic paper offers numerous advantages such as high specific surface area (resulting in large dynamic range), excellent wicking properties (naturally microfluidic), mechanical flexibility, compatibility with conventional printing approaches (enabling multiplexed detection and multimarker biochips), and significant cost reduction.

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Published In

Anal Chem

DOI

EISSN

1520-6882

Publication Date

November 20, 2012

Volume

84

Issue

22

Start / End Page

9928 / 9934

Location

United States

Related Subject Headings

  • Urinalysis
  • Surface Plasmon Resonance
  • Paper
  • Nanotubes
  • Limit of Detection
  • Kidney Neoplasms
  • Immunoglobulin G
  • Humans
  • Gold
  • Filtration
 

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Tian, L., Morrissey, J. J., Kattumenu, R., Gandra, N., Kharasch, E. D., & Singamaneni, S. (2012). Bioplasmonic paper as a platform for detection of kidney cancer biomarkers. Anal Chem, 84(22), 9928–9934. https://doi.org/10.1021/ac302332g
Tian, Limei, Jeremiah J. Morrissey, Ramesh Kattumenu, Naveen Gandra, Evan D. Kharasch, and Srikanth Singamaneni. “Bioplasmonic paper as a platform for detection of kidney cancer biomarkers.Anal Chem 84, no. 22 (November 20, 2012): 9928–34. https://doi.org/10.1021/ac302332g.
Tian L, Morrissey JJ, Kattumenu R, Gandra N, Kharasch ED, Singamaneni S. Bioplasmonic paper as a platform for detection of kidney cancer biomarkers. Anal Chem. 2012 Nov 20;84(22):9928–34.
Tian, Limei, et al. “Bioplasmonic paper as a platform for detection of kidney cancer biomarkers.Anal Chem, vol. 84, no. 22, Nov. 2012, pp. 9928–34. Pubmed, doi:10.1021/ac302332g.
Tian L, Morrissey JJ, Kattumenu R, Gandra N, Kharasch ED, Singamaneni S. Bioplasmonic paper as a platform for detection of kidney cancer biomarkers. Anal Chem. 2012 Nov 20;84(22):9928–9934.
Journal cover image

Published In

Anal Chem

DOI

EISSN

1520-6882

Publication Date

November 20, 2012

Volume

84

Issue

22

Start / End Page

9928 / 9934

Location

United States

Related Subject Headings

  • Urinalysis
  • Surface Plasmon Resonance
  • Paper
  • Nanotubes
  • Limit of Detection
  • Kidney Neoplasms
  • Immunoglobulin G
  • Humans
  • Gold
  • Filtration