Acute intravascular volume expansion with rapidly administered crystalloid or colloid in the setting of moderate hypovolemia.
Published
Journal Article
UNLABELLED: Although the distribution of various crystalloid and colloid solutions at equilibrium has been well established, the acute peak expansion of intravascular volume that can be achieved with the rapid administration of crystalloid or colloid is unknown. We studied eight healthy male subjects in a two-part crossover trial designed to assess the maximal increase in intravascular volume achieved with 1000 mL of lactated Ringer's solution compared with the same volume of 6% Hetastarch. Subjects were made moderately hypovolemic by the withdrawal of 900 mL of blood, and then the crystalloid or colloid solution was rapidly infused over 5-7 min. Serial dilution of hematocrit was measured every 5 min for 30 min to determine changes in blood volume. Peak expansion of intravascular volume with lactated Ringer's solution was 630 +/- 127 mL, occurring immediately the rapid infusion was complete, whereas the peak expansion of intravascular volume with 6% Hetastarch was 1123 +/- 116 mL and occurred 5 min after the completion of the fluid infusion. The results were significantly different (P < 0.001). These results would suggest that even for very short periods of time, rapid infusion of colloid significantly more effectively increases blood volume and, by inference, cardiac output than the same volume of crystalloid, even if the crystalloid is administered very rapidly. IMPLICATIONS: Under conditions of moderate hypovolemia, the maximal acute intravascular volume expansion with the rapid infusion of 1000 mL of lactated Ringer's solution is slightly more than half that achieved with the same volume of 6% Hetastarch.
Full Text
Duke Authors
Cited Authors
- McIlroy, DR; Kharasch, ED
Published Date
- June 2003
Published In
Volume / Issue
- 96 / 6
Start / End Page
- 1572 - 1577
PubMed ID
- 12760977
Pubmed Central ID
- 12760977
International Standard Serial Number (ISSN)
- 0003-2999
Digital Object Identifier (DOI)
- 10.1213/01.ane.0000061460.59320.b0
Language
- eng
Conference Location
- United States