Automated radiosynthesis of [11C]morphine for clinical investigation.
Journal Article (Journal Article)
To meet a multiple-dose clinical evaluation of the P-gp modulation of [(11)C]morphine delivery into the human brain, radiosynthesis of [(11)C]morphine was accomplished on an automated system by N-methylation of normorphine with [(11)C]CH(3)I. A methodology employing optimized solid phase extraction of the HPLC eluent was developed. Radiosynthesis took 45 min with a radiochemical yield ranging from 45% to 50% and specific activity ranging from 20 to 26 Ci/μmol (decay corrected to end-of-bombardment); radiochemical and chemical purities were >95% (n=28).
Full Text
Duke Authors
Cited Authors
- Fan, J; Meissner, K; Gaehle, GG; Li, S; Kharasch, ED; Mach, RH; Tu, Z
Published Date
- February 2011
Published In
Volume / Issue
- 69 / 2
Start / End Page
- 431 - 435
PubMed ID
- 21112214
Pubmed Central ID
- PMC3026438
Electronic International Standard Serial Number (EISSN)
- 1872-9800
Digital Object Identifier (DOI)
- 10.1016/j.apradiso.2010.11.003
Language
- eng
Conference Location
- England