Automated radiosynthesis of [11C]morphine for clinical investigation.

Journal Article (Journal Article)

To meet a multiple-dose clinical evaluation of the P-gp modulation of [(11)C]morphine delivery into the human brain, radiosynthesis of [(11)C]morphine was accomplished on an automated system by N-methylation of normorphine with [(11)C]CH(3)I. A methodology employing optimized solid phase extraction of the HPLC eluent was developed. Radiosynthesis took 45 min with a radiochemical yield ranging from 45% to 50% and specific activity ranging from 20 to 26 Ci/μmol (decay corrected to end-of-bombardment); radiochemical and chemical purities were >95% (n=28).

Full Text

Duke Authors

Cited Authors

  • Fan, J; Meissner, K; Gaehle, GG; Li, S; Kharasch, ED; Mach, RH; Tu, Z

Published Date

  • February 2011

Published In

Volume / Issue

  • 69 / 2

Start / End Page

  • 431 - 435

PubMed ID

  • 21112214

Pubmed Central ID

  • PMC3026438

Electronic International Standard Serial Number (EISSN)

  • 1872-9800

Digital Object Identifier (DOI)

  • 10.1016/j.apradiso.2010.11.003


  • eng

Conference Location

  • England