A community approach to mortality prediction in sepsis via gene expression analysis.

Journal Article (Journal Article)

Improved risk stratification and prognosis prediction in sepsis is a critical unmet need. Clinical severity scores and available assays such as blood lactate reflect global illness severity with suboptimal performance, and do not specifically reveal the underlying dysregulation of sepsis. Here, we present prognostic models for 30-day mortality generated independently by three scientific groups by using 12 discovery cohorts containing transcriptomic data collected from primarily community-onset sepsis patients. Predictive performance is validated in five cohorts of community-onset sepsis patients in which the models show summary AUROCs ranging from 0.765-0.89. Similar performance is observed in four cohorts of hospital-acquired sepsis. Combining the new gene-expression-based prognostic models with prior clinical severity scores leads to significant improvement in prediction of 30-day mortality as measured via AUROC and net reclassification improvement index These models provide an opportunity to develop molecular bedside tests that may improve risk stratification and mortality prediction in patients with sepsis.

Full Text

Duke Authors

Cited Authors

  • Sweeney, TE; Perumal, TM; Henao, R; Nichols, M; Howrylak, JA; Choi, AM; Bermejo-Martin, JF; Almansa, R; Tamayo, E; Davenport, EE; Burnham, KL; Hinds, CJ; Knight, JC; Woods, CW; Kingsmore, SF; Ginsburg, GS; Wong, HR; Parnell, GP; Tang, B; Moldawer, LL; Moore, FE; Omberg, L; Khatri, P; Tsalik, EL; Mangravite, LM; Langley, RJ

Published Date

  • February 15, 2018

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • 694 -

PubMed ID

  • 29449546

Pubmed Central ID

  • PMC5814463

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/s41467-018-03078-2


  • eng

Conference Location

  • England