Multicenter evaluation of the clinical utility of laparoscopy-assisted ERCP in patients with Roux-en-Y gastric bypass.

Journal Article (Journal Article;Multicenter Study)

BACKGROUND AND AIMS: The obesity epidemic has led to increased use of Roux-en-Y gastric bypass (RYGB). These patients have an increased incidence of pancreaticobiliary diseases, yet standard ERCP is not possible because of surgically altered gastroduodenal anatomy. Laparoscopy-assisted ERCP (LA-ERCP) has been proposed as an option, but supporting data are derived from single-center small case series. Therefore, we conducted a large multicenter study to evaluate the feasibility, safety, and outcomes of LA-ERCP. METHODS: This is a retrospective cohort study of adult patients with RYGB who underwent LA-ERCP in 34 centers. Data on demographics, indications, procedure success, and adverse events were collected. Procedure success was defined when all the following were achieved: reaching the papilla, cannulating the desired duct, and providing endoscopic therapy as clinically indicated. RESULTS: A total of 579 patients (median age, 51; 84% women) were included. Indication for LA-ERCP was biliary in 89%, pancreatic in 8%, and both in 3%. Procedure success was achieved in 98%. Median total procedure time was 152 minutes (interquartile range [IQR], 109-210), with a median ERCP time of 40 minutes (IQR, 28-56). Median hospital stay was 2 days (IQR, 1-3). Adverse events were 18% (laparoscopy related, 10%; ERCP related, 7%; both, 1%) with the clear majority (92%) classified as mild/moderate, whereas 8% were severe and 1 death occurred. CONCLUSIONS: Our large multicenter study indicates that LA-ERCP in patients with RYGB is feasible with a high procedure success rate comparable with that of standard ERCP in patients with normal anatomy. The ERCP-related adverse events rate is comparable with conventional ERCP, but the overall adverse event rate was higher because of the added laparoscopy-related events.

Full Text

Duke Authors

Cited Authors

  • Abbas, AM; Strong, AT; Diehl, DL; Brauer, BC; Lee, IH; Burbridge, R; Zivny, J; Higa, JT; Falcão, M; El Hajj, II; Tarnasky, P; Enestvedt, BK; Ende, AR; Thaker, AM; Pawa, R; Jamidar, P; Sampath, K; de Moura, EGH; Kwon, RS; Suarez, AL; Aburajab, M; Wang, AY; Shakhatreh, MH; Kaul, V; Kang, L; Kowalski, TE; Pannala, R; Tokar, J; Aadam, AA; Tzimas, D; Wagh, MS; Draganov, PV; LA-ERCP Research Group,

Published Date

  • April 2018

Published In

Volume / Issue

  • 87 / 4

Start / End Page

  • 1031 - 1039

PubMed ID

  • 29129525

Electronic International Standard Serial Number (EISSN)

  • 1097-6779

Digital Object Identifier (DOI)

  • 10.1016/j.gie.2017.10.044


  • eng

Conference Location

  • United States