Sortex: Efficient timing-driven synthesis of reconfigurable flow-based biochips for scalable single-cell screening

Published

Conference Paper

© 2017 IEEE. Single-cell screening is used to sort a stream of cells into clusters (or types) based on pre-specified biomarkers, thus supporting type-driven biochemical analysis. Reconfigurable flow-based microfluidic biochips (RFBs) can be utilized to screen hundreds of heterogeneous cells within a few minutes, but they are overburdened with the control of a large number of valves. To address this problem, we present a pin-constrained RFB design methodology for single-cell screening. The proposed design is analyzed using computational fluid dynamics simulations, mapped to an RC-lumped model, and combined with a high-level synthesis framework, referred to as Sortex. Simulation results show that Sortex significantly reduces the number of control pins and fulfills the timing requirements of single-cell screening.

Full Text

Duke Authors

Cited Authors

  • Ibrahim, M; Sridhar, A; Chakrabarty, K; Schlichtmann, U

Published Date

  • December 13, 2017

Published In

Volume / Issue

  • 2017-November /

Start / End Page

  • 623 - 630

International Standard Serial Number (ISSN)

  • 1092-3152

International Standard Book Number 13 (ISBN-13)

  • 9781538630938

Digital Object Identifier (DOI)

  • 10.1109/ICCAD.2017.8203835

Citation Source

  • Scopus