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Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial.

Publication ,  Journal Article
Chondronikola, M; Magkos, F; Yoshino, J; Okunade, AL; Patterson, BW; Muehlbauer, MJ; Newgard, CB; Klein, S
Published in: Obesity (Silver Spring)
April 2018

OBJECTIVE: Lactate is an intermediate of glucose metabolism that has been implicated in the pathogenesis of insulin resistance. This study evaluated the relationship between glucose kinetics and plasma lactate concentration ([LAC]) before and after manipulating insulin sensitivity by progressive weight loss. METHODS: Forty people with obesity (BMI = 37.9 ± 4.3 kg/m2 ) were randomized to weight maintenance (n = 14) or weight loss (n = 19). Subjects were studied before and after 6 months of weight maintenance and before and after 5%, 11%, and 16% weight loss. A hyperinsulinemic-euglycemic clamp procedure in conjunction with [6,6-2 H2 ]glucose tracer infusion was used to assess glucose kinetics. RESULTS: At baseline, fasting [LAC] correlated positively with endogenous glucose production rate (r = 0.532; P = 0.001) and negatively with insulin sensitivity, assessed as the insulin-stimulated glucose disposal (r = -0.361; P = 0.04). Progressive (5% through 16%) weight loss caused a progressive decrease in fasting [LAC], and the decrease in fasting [LAC] after 5% weight loss was correlated with the decrease in endogenous glucose production (r = 0.654; P = 0.002) and the increase in insulin sensitivity (r = -0.595; P = 0.007). CONCLUSIONS: This study demonstrates the interrelationships among weight loss, hepatic and muscle glucose kinetics, insulin sensitivity, and [LAC], and it suggests that [LAC] can serve as an additional biomarker of glucose-related insulin resistance.

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Published In

Obesity (Silver Spring)

DOI

EISSN

1930-739X

Publication Date

April 2018

Volume

26

Issue

4

Start / End Page

683 / 688

Location

United States

Related Subject Headings

  • Weight Loss
  • Male
  • Lactates
  • Insulin Resistance
  • Humans
  • Glucose Clamp Technique
  • Female
  • Endocrinology & Metabolism
  • Adult
 

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Chondronikola, M., Magkos, F., Yoshino, J., Okunade, A. L., Patterson, B. W., Muehlbauer, M. J., … Klein, S. (2018). Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial. Obesity (Silver Spring), 26(4), 683–688. https://doi.org/10.1002/oby.22129
Chondronikola, Maria, Faidon Magkos, Jun Yoshino, Adewole L. Okunade, Bruce W. Patterson, Michael J. Muehlbauer, Christopher B. Newgard, and Samuel Klein. “Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial.Obesity (Silver Spring) 26, no. 4 (April 2018): 683–88. https://doi.org/10.1002/oby.22129.
Chondronikola M, Magkos F, Yoshino J, Okunade AL, Patterson BW, Muehlbauer MJ, et al. Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial. Obesity (Silver Spring). 2018 Apr;26(4):683–8.
Chondronikola, Maria, et al. “Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial.Obesity (Silver Spring), vol. 26, no. 4, Apr. 2018, pp. 683–88. Pubmed, doi:10.1002/oby.22129.
Chondronikola M, Magkos F, Yoshino J, Okunade AL, Patterson BW, Muehlbauer MJ, Newgard CB, Klein S. Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial. Obesity (Silver Spring). 2018 Apr;26(4):683–688.
Journal cover image

Published In

Obesity (Silver Spring)

DOI

EISSN

1930-739X

Publication Date

April 2018

Volume

26

Issue

4

Start / End Page

683 / 688

Location

United States

Related Subject Headings

  • Weight Loss
  • Male
  • Lactates
  • Insulin Resistance
  • Humans
  • Glucose Clamp Technique
  • Female
  • Endocrinology & Metabolism
  • Adult