A rare CALR variant mutation and a review of CALR in essential thrombocythemia.


Journal Article (Review)

Essential thrombocythemia (ET) is an indolent myeloproliferative neoplasm characterized by megakaryocyte hyperplasia, thrombocytosis, thrombotic and hemorrhagic complications, and potential transformation into myelofibrosis and acute myeloid leukemia. The vast majority of cases are driven by a somatic mutation in JAK2, CALR, or MPL. CALR, a gene that codes for the calcium-binding chaperone calreticulin, is the predominant mutation in patients with non-mutated JAK2 essential thrombocythemia, accounting for 20-25% of the overall somatic mutation frequency in ET. In this brief review of ET, we introduce a rare CALR mutation through a case presentation of a 58-year-old man with diffuse pulmonary emboli in the setting of thrombocytosis. We subsequently characterize the main types of CALR mutations and their value in diagnosis and prognosis of disease course, and lastly discuss the current clinical approach to ET.

Full Text

Duke Authors

Cited Authors

  • Diep, R; Metjian, A

Published Date

  • April 2018

Published In

Volume / Issue

  • 45 / 3

Start / End Page

  • 457 - 462

PubMed ID

  • 29411299

Pubmed Central ID

  • 29411299

Electronic International Standard Serial Number (EISSN)

  • 1573-742X

Digital Object Identifier (DOI)

  • 10.1007/s11239-018-1619-0


  • eng

Conference Location

  • Netherlands