Towards a general model for predicting the toxicity and pathogenicity of mineral fibres


Conference Paper

© 2017 the European Mineralogical Union. This chapter provides a comprehensive description of the physical, chemical, biological and mineralogical parameters that play a role in determining the toxicity and pathogenicity of mineral fibres. The first steps towards a general toxicity/pathogenicity model of mineral fibres are described here. Eventually the model can be generalized and may be applied to biodurable man-made mineral fibres and other natural and synthetic fibres in addition to silicates. Because of the complexity of the topic, a truly multidisciplinary approach is essential. A concept that will be stressed in the final notes of the chapter is that a full understanding of the toxicity/pathogenicity of mineral fibres aimed at finding effective solutions for the prevention and treatment of asbestos-related diseases can only be the outcome if an holistic approach is applied which takes advantage of synergistic research activity and communication between biochemists, mineralogists/crystallographers, pathologists, physicians, physicists and toxicologists, all sharing their distinct but interrelated perspectives. This is a great challenge for all such scientific individuals to work together to resolve and develop predictive models that incorporate their research findings and conclusions.

Full Text

Duke Authors

Cited Authors

  • Gualtieri, AF; Mossman, BT; Roggli, VL

Published Date

  • January 1, 2017

Published In

Volume / Issue

  • 18 /

Start / End Page

  • 501 - 532

International Standard Serial Number (ISSN)

  • 1417-2917

International Standard Book Number 13 (ISBN-13)

  • 9780903056656

Digital Object Identifier (DOI)

  • 10.1180/EMU-notes.18.15

Citation Source

  • Scopus