Treatment dynamics of bone-targeting agents among men with bone metastases from prostate cancer in the United States.


Journal Article

PURPOSE:To examine the dynamics of treatment with 2 bone-targeting agents (BTAs)-denosumab and zoledronic acid-among men with bone metastases from prostate cancer. METHODS:Using electronic health record data from oncology practices across the US, we identified prostate cancer patients diagnosed with bone metastasis in 2012/2013 without evidence of BTA use within 6 months prior to diagnosis. We examined the risk and predictors of BTA initiation, interruption, and re-initiation. RESULTS:Among 897 men diagnosed with prostate cancer, the cumulative incidence of BTA initiation after bone metastasis diagnosis was 34% (95% confidence interval [CI], 31-37%) at 30 days, 64% (95% CI, 61-68%) at 180 days, and 88% (95% CI, 85-91%) at 2 years. Denosumab was initiated more frequently than zoledronic acid. Men with diabetes, more bone lesions, history of androgen deprivation therapy, or no hospice enrollment were more likely to initiate treatment. Following initiation, the cumulative incidence of treatment interruption was 17% (95% CI, 14-19%) at 60 days and 70% (95% CI, 66-74%) at 2 years, with interruption more likely among patients receiving emerging therapies for prostate cancer or enrolling in hospice. The cumulative incidence of re-initiation following interruption was 36.3% (95% CI, 32.7-40.2%) at 15 days, 49.8% (95% CI, 45.9-54.1%) at 30 days, and 81.0% (95% CI, 77.5-84.7%) at 1 year. CONCLUSIONS:Bone-targeting agent therapy is initiated by the majority of men living with bone metastases following a prostate cancer diagnosis; however, the timing of initiation is highly variable. Once on treatment, gaps or interruptions in therapy are common.

Full Text

Cited Authors

  • Butler, AM; Cetin, K; Hernandez, RK; Diane Reams, B; Overman, RA; I Kim, J; Hirsch, BR; Abernethy, AP; Liede, A; Alan Brookhart, M

Published Date

  • February 2018

Published In

Volume / Issue

  • 27 / 2

Start / End Page

  • 229 - 238

PubMed ID

  • 29316026

Pubmed Central ID

  • 29316026

Electronic International Standard Serial Number (EISSN)

  • 1099-1557

International Standard Serial Number (ISSN)

  • 1053-8569

Digital Object Identifier (DOI)

  • 10.1002/pds.4360


  • eng