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Periconceptional use of folic acid and risk of miscarriage - findings of the Oral Cleft Prevention Program in Brazil.

Publication ,  Journal Article
Vila-Nova, C; Wehby, GL; Queirós, FC; Chakraborty, H; Félix, TM; Goco, N; Moore, J; Gewehr, EV; Lins, L; Affonso, CMC; Murray, JC
Published in: J Perinat Med
July 2013

OBJECTIVE: We report on the risk of miscarriage with high- and low-dosage periconceptional folic acid (FA) supplementation from a double-blind randomized clinical trial for prevention of orofacial cleft recurrence in Brazil. METHODS: Women at risk of recurrence of orofacial clefts in their offspring were randomized into high (4 mg/day) and low (0.4 mg/day) doses of FA supplementation. The women received the study pills before pregnancy, and supplementation continued throughout the first trimester. Miscarriage rates were compared between the two FA groups and with the population rate. RESULTS: A total of 268 pregnancies completed the study protocol, with 141 in the 4.0-mg group and 127 in the 0.4-mg group. The miscarriage rate was 14.2% in the low-dose FA group (0.4 mg/day) and 11.3% for the high-dose group (4 mg/day) (P=0.4877). These miscarriage rates are not significantly different from the miscarriage rate in the Brazilian population, estimated to be around 14% (P=0.311). CONCLUSIONS: These results indicate that high-dose FA does not increase miscarriage risk in this population and add further information to the literature on the safety of high FA supplementation for prevention of birth defect recurrence.

Duke Scholars

Published In

J Perinat Med

DOI

EISSN

1619-3997

Publication Date

July 2013

Volume

41

Issue

4

Start / End Page

461 / 466

Location

Germany

Related Subject Headings

  • Young Adult
  • Recurrence
  • Pregnancy
  • Preconception Care
  • Obstetrics & Reproductive Medicine
  • Male
  • Infant, Newborn
  • Humans
  • Folic Acid
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Vila-Nova, C., Wehby, G. L., Queirós, F. C., Chakraborty, H., Félix, T. M., Goco, N., … Murray, J. C. (2013). Periconceptional use of folic acid and risk of miscarriage - findings of the Oral Cleft Prevention Program in Brazil. J Perinat Med, 41(4), 461–466. https://doi.org/10.1515/jpm-2012-0173
Vila-Nova, Camila, George L. Wehby, Fernanda C. Queirós, Hrishkesh Chakraborty, Temis M. Félix, Norman Goco, Janet Moore, et al. “Periconceptional use of folic acid and risk of miscarriage - findings of the Oral Cleft Prevention Program in Brazil.J Perinat Med 41, no. 4 (July 2013): 461–66. https://doi.org/10.1515/jpm-2012-0173.
Vila-Nova C, Wehby GL, Queirós FC, Chakraborty H, Félix TM, Goco N, et al. Periconceptional use of folic acid and risk of miscarriage - findings of the Oral Cleft Prevention Program in Brazil. J Perinat Med. 2013 Jul;41(4):461–6.
Vila-Nova, Camila, et al. “Periconceptional use of folic acid and risk of miscarriage - findings of the Oral Cleft Prevention Program in Brazil.J Perinat Med, vol. 41, no. 4, July 2013, pp. 461–66. Pubmed, doi:10.1515/jpm-2012-0173.
Vila-Nova C, Wehby GL, Queirós FC, Chakraborty H, Félix TM, Goco N, Moore J, Gewehr EV, Lins L, Affonso CMC, Murray JC. Periconceptional use of folic acid and risk of miscarriage - findings of the Oral Cleft Prevention Program in Brazil. J Perinat Med. 2013 Jul;41(4):461–466.
Journal cover image

Published In

J Perinat Med

DOI

EISSN

1619-3997

Publication Date

July 2013

Volume

41

Issue

4

Start / End Page

461 / 466

Location

Germany

Related Subject Headings

  • Young Adult
  • Recurrence
  • Pregnancy
  • Preconception Care
  • Obstetrics & Reproductive Medicine
  • Male
  • Infant, Newborn
  • Humans
  • Folic Acid
  • Female