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Neurodevelopmental outcomes in infants requiring resuscitation in developing countries.

Publication ,  Journal Article
Carlo, WA; Goudar, SS; Pasha, O; Chomba, E; McClure, EM; Biasini, FJ; Wallander, JL; Thorsten, V; Chakraborty, H; Wright, LL ...
Published in: J Pediatr
May 2012

OBJECTIVE: To determine whether resuscitation of infants who failed to develop effective breathing at birth increases survivors with neurodevelopmental impairment. STUDY DESIGN: Infants unresponsive to stimulation who received bag and mask ventilation at birth in a resuscitation trial and infants who did not require any resuscitation were randomized to early neurodevelopmental intervention or control groups. Infants were examined by trained neurodevelopmental evaluators masked to both their resuscitation history and intervention group. The 12-month neurodevelopmental outcome data for both resuscitated and non-resuscitated infants randomized to the control groups are reported. RESULTS: The study provided no evidence of a difference between the resuscitated infants (n = 86) and the non-resuscitated infants (n = 115) in the percentage of infants at 12 months with a Mental Developmental Index <85 on the Bayley Scales of Infant Development-II (primary outcome; 18% versus 12%; P = .22) and in other neurodevelopmental outcomes. CONCLUSIONS: Most infants who received resuscitation with bag and mask ventilation at birth have 12-month neurodevelopmental outcomes in the reference range. Longer follow-up is needed because of increased risk for neurodevelopmental impairments.

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Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

May 2012

Volume

160

Issue

5

Start / End Page

781 / 5.e1

Location

United States

Related Subject Headings

  • Zambia
  • Survival Analysis
  • Severity of Illness Index
  • Rural Population
  • Risk Assessment
  • Resuscitation
  • Respiratory Distress Syndrome, Newborn
  • Reference Values
  • Pediatrics
  • Pakistan
 

Citation

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Carlo, W. A., Goudar, S. S., Pasha, O., Chomba, E., McClure, E. M., Biasini, F. J., … National Institute of Child Health and Human Development Global Network for Women’s and Children’s Health Research, . (2012). Neurodevelopmental outcomes in infants requiring resuscitation in developing countries. J Pediatr, 160(5), 781-5.e1. https://doi.org/10.1016/j.jpeds.2011.10.007
Carlo, Waldemar A., Shivaprasad S. Goudar, Omrana Pasha, Elwyn Chomba, Elizabeth M. McClure, Fred J. Biasini, Jan L. Wallander, et al. “Neurodevelopmental outcomes in infants requiring resuscitation in developing countries.J Pediatr 160, no. 5 (May 2012): 781-5.e1. https://doi.org/10.1016/j.jpeds.2011.10.007.
Carlo WA, Goudar SS, Pasha O, Chomba E, McClure EM, Biasini FJ, et al. Neurodevelopmental outcomes in infants requiring resuscitation in developing countries. J Pediatr. 2012 May;160(5):781-5.e1.
Carlo, Waldemar A., et al. “Neurodevelopmental outcomes in infants requiring resuscitation in developing countries.J Pediatr, vol. 160, no. 5, May 2012, pp. 781-5.e1. Pubmed, doi:10.1016/j.jpeds.2011.10.007.
Carlo WA, Goudar SS, Pasha O, Chomba E, McClure EM, Biasini FJ, Wallander JL, Thorsten V, Chakraborty H, Wright LL, Brain Research to Ameliorate Impaired Neurodevelopment-Home-based Intervention Trial Committee, National Institute of Child Health and Human Development Global Network for Women’s and Children’s Health Research. Neurodevelopmental outcomes in infants requiring resuscitation in developing countries. J Pediatr. 2012 May;160(5):781–5.e1.
Journal cover image

Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

May 2012

Volume

160

Issue

5

Start / End Page

781 / 5.e1

Location

United States

Related Subject Headings

  • Zambia
  • Survival Analysis
  • Severity of Illness Index
  • Rural Population
  • Risk Assessment
  • Resuscitation
  • Respiratory Distress Syndrome, Newborn
  • Reference Values
  • Pediatrics
  • Pakistan