The decline of typhoid and the rise of non-typhoid salmonellae and fungal infections in a changing HIV landscape: bloodstream infection trends over 15 years in southern Vietnam.

Published

Journal Article

The etiological spectrum of bloodstream infections is variable between industrialized and developing countries and even within a defined location over time. We investigated trends in bloodstream infections at an infectious disease hospital in Ho Chi Minh City, Vietnam, from 1994-2008. Amongst 66,111 blood cultures performed, a clinically relevant pathogen was isolated in 7645 episodes (positivity rate; 116/1000 cultures). Salmonella Typhi was the predominant pathogen until 2002; however, a considerable annual decline in the proportion of S. Typhi was observed (OR 0.6993, 95% CI [0.6885, 0.7103], p<0.0001). Conversely, there was a significant increase in the proportions of non-typhoidal Salmonella (NTS), Cryptococcus neoformans and Penicillium marneffei, concurrent with increasing HIV prevalence. These data document a substantial longitudinal shift in bloodstream infection etiology in southern Vietnam. We propose such changes are related to increasing economic prosperity and HIV prevalence, and this pattern marks a substantial change in the epidemiology of invasive salmonellosis in Southeast Asia.

Full Text

Duke Authors

Cited Authors

  • Nga, TVT; Parry, CM; Le, T; Lan, NPH; Diep, TS; Campbell, JI; Hoang, NVM; Dung, LT; Wain, J; Dolecek, C; Farrar, JJ; Chau, NVV; Hien, TT; Day, JN; Baker, S

Published Date

  • January 2012

Published In

Volume / Issue

  • 106 / 1

Start / End Page

  • 26 - 34

PubMed ID

  • 22137537

Pubmed Central ID

  • 22137537

Electronic International Standard Serial Number (EISSN)

  • 1878-3503

International Standard Serial Number (ISSN)

  • 0035-9203

Digital Object Identifier (DOI)

  • 10.1016/j.trstmh.2011.10.004

Language

  • eng