Identification and expression of voltage-gated calcium channel beta subunits in Zebrafish.

Journal Article

Voltage-gated calcium channels (VGCC) play important roles in electrically excitable cells and embryonic development. The VGCC beta subunits are essential for membrane localization of the channel and exert modulatory effects on channel functions. In mammals, the VGCC beta subunit gene family contains four members. In zebrafish, there appear to be seven VGCC beta subunits including the previously identified beta1 subunit. cDNAs for six additional VGCC beta subunit homologs were identified in zebrafish, their chromosomal locations determined and their expression patterns characterized during embryonic development. These six genes are primarily expressed in the nervous system with cacnb4a also expressed in the developing heart. Sequence homology, genomic synteny and expression patterns suggest that there are three pairs of duplicate genes for beta2, beta3, and beta4 in zebrafish with distinct expression patterns during embryonic development.

Full Text

Duke Authors

Cited Authors

  • Zhou, W; Horstick, EJ; Hirata, H; Kuwada, JY

Published Date

  • December 2008

Published In

Volume / Issue

  • 237 / 12

Start / End Page

  • 3842 - 3852

PubMed ID

  • 19035348

Electronic International Standard Serial Number (EISSN)

  • 1097-0177

International Standard Serial Number (ISSN)

  • 1058-8388

Digital Object Identifier (DOI)

  • 10.1002/dvdy.21776

Language

  • eng