Six-minute walk distance after coronary artery bypass grafting compared with medical therapy in ischaemic cardiomyopathy.

Published online

Journal Article

Background: In patients with ischaemic left ventricular dysfunction, coronary artery bypass surgery (CABG) may decrease mortality, but it is not known whether CABG improves functional capacity. Objective: To determine whether CABG compared with medical therapy alone (MED) increases 6 min walk distance in patients with ischaemic left ventricular dysfunction and coronary artery disease amenable to revascularisation. Methods: The Surgical Treatment in Ischemic Heart disease trial randomised 1212 patients with ischaemic left ventricular dysfunction to CABG or MED. A 6 min walk distance test was performed both at baseline and at least one follow-up assessment at 4, 12, 24 and/or 36 months in 409 patients randomised to CABG and 466 to MED. Change in 6 min walk distance between baseline and follow-up were compared by treatment allocation. Results: 6 min walk distance at baseline for CABG was mean 340±117 m and for MED 339±118 m. Change in walk distance from baseline was similar for CABG and MED groups at 4 months (mean +38 vs +28 m), 12 months (+47 vs +36 m), 24 months (+31 vs +34 m) and 36 months (-7 vs +7 m), P>0.10 for all. Change in walk distance between CABG and MED groups over all assessments was also similar after adjusting for covariates and imputation for missing values (+8 m, 95% CI -7 to 23 m, P=0.29). Results were consistent for subgroups defined by angina, New York Heart Association class ≥3, left ventricular ejection fraction, baseline walk distance and geographic region. Conclusion: In patients with ischaemic left ventricular dysfunction CABG compared with MED alone is known to reduce mortality but is unlikely to result in a clinically significant improvement in functional capacity. Trial registration number: NCT00023595.

Full Text

Duke Authors

Cited Authors

  • Stewart, RAH; Szalewska, D; Stebbins, A; Al-Khalidi, HR; Cleland, JGH; Rynkiewicz, A; Drazner, MH; White, HD; Mark, DB; Roy, A; Kosevic, D; Rajda, M; Jasinski, M; Leng, CY; Tungsubutra, W; Desvigne-Nickens, P; Velazquez, EJ; Petrie, MC

Published Date

  • 2018

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • e000752 -

PubMed ID

  • 29531766

Pubmed Central ID

  • 29531766

International Standard Serial Number (ISSN)

  • 2053-3624

Digital Object Identifier (DOI)

  • 10.1136/openhrt-2017-000752


  • eng

Conference Location

  • England