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Synthetic efforts towards the stereoselective synthesis of NF00659B1.

Publication ,  Journal Article
Kwon, D-Y; Lee, K; Park, H; Kim, MJ; Hong, J
Published in: Bioorganic & medicinal chemistry letters
September 2018

NF00659B1 is a novel α-pyrone diterpenoid natural product with potent anti-colon cancer activity. A stereoselective approach to the 2,2-dimethyl oxepanol core of NF00659B1 is described enlisting a sequence of olefinic ester ring-closing metathesis, epoxidation, and Grignard addition. This strategy paves the way to a total synthesis of NF00659B1 for further biological studies.

Duke Scholars

Published In

Bioorganic & medicinal chemistry letters

DOI

EISSN

1464-3405

ISSN

0960-894X

Publication Date

September 2018

Volume

28

Issue

16

Start / End Page

2746 / 2750

Related Subject Headings

  • Stereoisomerism
  • Molecular Conformation
  • Medicinal & Biomolecular Chemistry
  • Biological Products
  • Alkenes
  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry
 

Citation

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ICMJE
MLA
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Kwon, D.-Y., Lee, K., Park, H., Kim, M. J., & Hong, J. (2018). Synthetic efforts towards the stereoselective synthesis of NF00659B1. Bioorganic & Medicinal Chemistry Letters, 28(16), 2746–2750. https://doi.org/10.1016/j.bmcl.2018.02.038
Kwon, Do-Yeon, Kiyoun Lee, Hyeri Park, Mi Jung Kim, and Jiyong Hong. “Synthetic efforts towards the stereoselective synthesis of NF00659B1.Bioorganic & Medicinal Chemistry Letters 28, no. 16 (September 2018): 2746–50. https://doi.org/10.1016/j.bmcl.2018.02.038.
Kwon D-Y, Lee K, Park H, Kim MJ, Hong J. Synthetic efforts towards the stereoselective synthesis of NF00659B1. Bioorganic & medicinal chemistry letters. 2018 Sep;28(16):2746–50.
Kwon, Do-Yeon, et al. “Synthetic efforts towards the stereoselective synthesis of NF00659B1.Bioorganic & Medicinal Chemistry Letters, vol. 28, no. 16, Sept. 2018, pp. 2746–50. Epmc, doi:10.1016/j.bmcl.2018.02.038.
Kwon D-Y, Lee K, Park H, Kim MJ, Hong J. Synthetic efforts towards the stereoselective synthesis of NF00659B1. Bioorganic & medicinal chemistry letters. 2018 Sep;28(16):2746–2750.
Journal cover image

Published In

Bioorganic & medicinal chemistry letters

DOI

EISSN

1464-3405

ISSN

0960-894X

Publication Date

September 2018

Volume

28

Issue

16

Start / End Page

2746 / 2750

Related Subject Headings

  • Stereoisomerism
  • Molecular Conformation
  • Medicinal & Biomolecular Chemistry
  • Biological Products
  • Alkenes
  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry