Synthetic efforts towards the stereoselective synthesis of NF00659B1 .

Journal Article (Journal Article)

NF00659B1 is a novel α-pyrone diterpenoid natural product with potent anti-colon cancer activity. A stereoselective approach to the 2,2-dimethyl oxepanol core of NF00659B1 is described enlisting a sequence of olefinic ester ring-closing metathesis, epoxidation, and Grignard addition. This strategy paves the way to a total synthesis of NF00659B1 for further biological studies.

Full Text

Duke Authors

Cited Authors

  • Kwon, D-Y; Lee, K; Park, H; Kim, MJ; Hong, J

Published Date

  • September 2018

Published In

Volume / Issue

  • 28 / 16

Start / End Page

  • 2746 - 2750

PubMed ID

  • 29503022

Pubmed Central ID

  • PMC6098985

Electronic International Standard Serial Number (EISSN)

  • 1464-3405

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2018.02.038


  • eng