Synthetic efforts towards the stereoselective synthesis of NF00659B1 .
Journal Article (Journal Article)
NF00659B1 is a novel α-pyrone diterpenoid natural product with potent anti-colon cancer activity. A stereoselective approach to the 2,2-dimethyl oxepanol core of NF00659B1 is described enlisting a sequence of olefinic ester ring-closing metathesis, epoxidation, and Grignard addition. This strategy paves the way to a total synthesis of NF00659B1 for further biological studies.
Full Text
Duke Authors
Cited Authors
- Kwon, D-Y; Lee, K; Park, H; Kim, MJ; Hong, J
Published Date
- September 2018
Published In
Volume / Issue
- 28 / 16
Start / End Page
- 2746 - 2750
PubMed ID
- 29503022
Pubmed Central ID
- PMC6098985
Electronic International Standard Serial Number (EISSN)
- 1464-3405
International Standard Serial Number (ISSN)
- 0960-894X
Digital Object Identifier (DOI)
- 10.1016/j.bmcl.2018.02.038
Language
- eng