Innate Antiviral Immunity in the Skin.

Journal Article (Journal Article;Review)

Barrier sites such as the skin play a critical role in immune defense. They must maintain homeostasis with commensals and rapidly detect and limit pathogen invasion. This is accomplished in part through the production of endogenous antimicrobial peptides and proteins, which can be either constitutive or inducible. Here, we focus particularly on the control of innate antiviral proteins and present the basic aspects of their regulation in the skin by interferons (IFNs), IFN-independent immunity, and environmental factors. We also discuss the activity and (dys-)function of antiviral proteins in the context of skin-tropic viruses and highlight the relevance of the innate antiviral pathway as a potential therapeutic avenue for vulnerable patient populations and skin diseases with high risk for virus infections.

Full Text

Duke Authors

Cited Authors

  • Handfield, C; Kwock, J; MacLeod, AS

Published Date

  • April 2018

Published In

Volume / Issue

  • 39 / 4

Start / End Page

  • 328 - 340

PubMed ID

  • 29526487

Pubmed Central ID

  • PMC5993211

Electronic International Standard Serial Number (EISSN)

  • 1471-4981

Digital Object Identifier (DOI)

  • 10.1016/


  • eng

Conference Location

  • England