Spatially resolved diffuse reflectance spectroscopy endoscopic sensing with custom Si photodetectors.

Journal Article (Journal Article)

Early detection and surveillance of disease progression in epithelial tissue is key to improving long term patient outcomes for colon and esophageal cancers, which account for nearly a quarter of cancer related mortalities worldwide. Spatially resolved diffuse reflectance spectroscopy (SRDRS) is a non-invasive optical technique to sense biological changes at the cellular and sub-cellular level that occur when normal tissue becomes diseased, and has the potential to significantly improve the current standard of care for endoscopic gastrointestinal (GI) screening. Herein the design, fabrication, and characterization of the first custom SRDRS device to enable endoscopic SRDRS GI tissue characterization using a custom silicon (Si) thin film multi-pixel endoscopic optical sensor (MEOS) is described.

Full Text

Duke Authors

Cited Authors

  • Lariviere, B; Garman, KS; Ferguson, NL; Fisher, DA; Jokerst, NM

Published Date

  • March 1, 2018

Published In

Volume / Issue

  • 9 / 3

Start / End Page

  • 1164 - 1176

PubMed ID

  • 29541510

Pubmed Central ID

  • PMC5846520

International Standard Serial Number (ISSN)

  • 2156-7085

Digital Object Identifier (DOI)

  • 10.1364/BOE.9.001164


  • eng

Conference Location

  • United States