Mapping Effector-Phenotype Landscapes in KRAS-Driven Cancers.
Publication
, Journal Article
Winter, PS; Wood, KC
Published in: Trends Cancer
May 2018
Oncogenic KRAS can activate numerous effector pathways to drive malignant progression. However, the relationships between specific effectors and oncogenic phenotypes, and the extent to which these relationships vary across heterogeneous tumors, are incompletely understood. Recently in Cell Reports, a team of scientists described an innovative, combinatorial siRNA-based approach to functionally link KRAS effectors and phenotypes in a large panel of cancer cell lines. Central to this work was the identification of two major subtypes of KRAS-mutant cancers with distinct effector landscapes and tractable therapeutic vulnerabilities.
Duke Scholars
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Published In
Trends Cancer
DOI
EISSN
2405-8025
Publication Date
May 2018
Volume
4
Issue
5
Start / End Page
333 / 335
Location
United States
Related Subject Headings
- Proto-Oncogene Proteins p21(ras)
- Phenotype
- Oncogenes
- Mutation
- Humans
- Cell Line, Tumor
- 3211 Oncology and carcinogenesis
- 1112 Oncology and Carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Winter, P. S., & Wood, K. C. (2018). Mapping Effector-Phenotype Landscapes in KRAS-Driven Cancers. Trends Cancer, 4(5), 333–335. https://doi.org/10.1016/j.trecan.2018.02.004
Winter, Peter S., and Kris C. Wood. “Mapping Effector-Phenotype Landscapes in KRAS-Driven Cancers.” Trends Cancer 4, no. 5 (May 2018): 333–35. https://doi.org/10.1016/j.trecan.2018.02.004.
Winter PS, Wood KC. Mapping Effector-Phenotype Landscapes in KRAS-Driven Cancers. Trends Cancer. 2018 May;4(5):333–5.
Winter, Peter S., and Kris C. Wood. “Mapping Effector-Phenotype Landscapes in KRAS-Driven Cancers.” Trends Cancer, vol. 4, no. 5, May 2018, pp. 333–35. Pubmed, doi:10.1016/j.trecan.2018.02.004.
Winter PS, Wood KC. Mapping Effector-Phenotype Landscapes in KRAS-Driven Cancers. Trends Cancer. 2018 May;4(5):333–335.
Published In
Trends Cancer
DOI
EISSN
2405-8025
Publication Date
May 2018
Volume
4
Issue
5
Start / End Page
333 / 335
Location
United States
Related Subject Headings
- Proto-Oncogene Proteins p21(ras)
- Phenotype
- Oncogenes
- Mutation
- Humans
- Cell Line, Tumor
- 3211 Oncology and carcinogenesis
- 1112 Oncology and Carcinogenesis