Mapping Effector-Phenotype Landscapes in KRAS-Driven Cancers.


Journal Article

Oncogenic KRAS can activate numerous effector pathways to drive malignant progression. However, the relationships between specific effectors and oncogenic phenotypes, and the extent to which these relationships vary across heterogeneous tumors, are incompletely understood. Recently in Cell Reports, a team of scientists described an innovative, combinatorial siRNA-based approach to functionally link KRAS effectors and phenotypes in a large panel of cancer cell lines. Central to this work was the identification of two major subtypes of KRAS-mutant cancers with distinct effector landscapes and tractable therapeutic vulnerabilities.

Full Text

Duke Authors

Cited Authors

  • Winter, PS; Wood, KC

Published Date

  • May 2018

Published In

Volume / Issue

  • 4 / 5

Start / End Page

  • 333 - 335

PubMed ID

  • 29709255

Pubmed Central ID

  • 29709255

Electronic International Standard Serial Number (EISSN)

  • 2405-8025

Digital Object Identifier (DOI)

  • 10.1016/j.trecan.2018.02.004


  • eng

Conference Location

  • United States