Chromatin Regulation of Neuronal Maturation and Plasticity.

Published

Journal Article (Review)

Neurons are dynamic cells that respond and adapt to stimuli throughout their long postmitotic lives. The structural and functional plasticity of neurons requires the regulated transcription of new gene products, and dysregulation of transcription in either the developing or adult brain impairs cognition. We discuss how mechanisms of chromatin regulation help to orchestrate the transcriptional programs that underlie the maturation of developing neurons and the plasticity of adult neurons. We review how chromatin regulation acts locally to modulate the expression of specific genes and more broadly to coordinate gene expression programs during transitions between cellular states. These data highlight the importance of epigenetic transcriptional mechanisms in postmitotic neurons. We suggest areas where emerging methods may advance understanding in the future.

Full Text

Duke Authors

Cited Authors

  • Gallegos, DA; Chan, U; Chen, L-F; West, AE

Published Date

  • May 2018

Published In

Volume / Issue

  • 41 / 5

Start / End Page

  • 311 - 324

PubMed ID

  • 29530320

Pubmed Central ID

  • 29530320

Electronic International Standard Serial Number (EISSN)

  • 1878-108X

International Standard Serial Number (ISSN)

  • 0166-2236

Digital Object Identifier (DOI)

  • 10.1016/j.tins.2018.02.009

Language

  • eng