Soluble ST2 in Heart Failure.

Published

Journal Article (Review)

Suppression of tumorigenicity 2 (ST2) is a member of the interleukin (IL)-1 receptor family, whose role was originally established in the context of inflammatory and autoimmune diseases. More recently, testing for ST2 has been used in the setting of cardiovascular disease. The soluble form of ST2 is a decoy receptor that inhibits beneficial cardioprotective effects of IL-33; such inhibition results in cardiac hypertrophy, myocardial fibrosis, and ventricular dysfunction. Measurement of soluble ST2 has utility for assessing heart failure severity and prognosis. In this review, we examine the role of soluble ST2 in both acute and chronic heart failure.

Full Text

Duke Authors

Cited Authors

  • McCarthy, CP; Januzzi, JL

Published Date

  • January 2018

Published In

Volume / Issue

  • 14 / 1

Start / End Page

  • 41 - 48

PubMed ID

  • 29153199

Pubmed Central ID

  • 29153199

International Standard Serial Number (ISSN)

  • 1551-7136

Digital Object Identifier (DOI)

  • 10.1016/j.hfc.2017.08.005

Language

  • eng

Conference Location

  • United States