Computational modeling of cardiac fibroblasts and fibrosis.

Journal Article (Journal Article;Review)

Altered fibroblast behavior can lead to pathologic changes in the heart such as arrhythmia, diastolic dysfunction, and systolic dysfunction. Computational models are increasingly used as a tool to identify potential mechanisms driving a phenotype or potential therapeutic targets against an unwanted phenotype. Here we review how computational models incorporating cardiac fibroblasts have clarified the role for these cells in electrical conduction and tissue remodeling in the heart. Models of fibroblast signaling networks have primarily focused on fibroblast cell lines or fibroblasts from other tissues rather than cardiac fibroblasts, specifically, but they are useful for understanding how fundamental signaling pathways control fibroblast phenotype. In the future, modeling cardiac fibroblast signaling, incorporating -omics and drug-interaction data into signaling network models, and utilizing multi-scale models will improve the ability of in silico studies to predict potential therapeutic targets against adverse cardiac fibroblast activity.

Full Text

Duke Authors

Cited Authors

  • Zeigler, AC; Richardson, WJ; Holmes, JW; Saucerman, JJ

Published Date

  • April 2016

Published In

Volume / Issue

  • 93 /

Start / End Page

  • 73 - 83

PubMed ID

  • 26608708

Pubmed Central ID

  • PMC4846515

Electronic International Standard Serial Number (EISSN)

  • 1095-8584

Digital Object Identifier (DOI)

  • 10.1016/j.yjmcc.2015.11.020


  • eng

Conference Location

  • England