Centromeres are essential to accurate segregation of genetic material in both meiosis and mitosis. Visually, the centromere is the site of constriction on metaphase chromosomes. Functionally, it is the site where the proteins of the kinetochore assemble to hold sister chromatids together and to guide chromosome movement during cell division. Despite such an essential role in chromosome stability, centromere sequence, structure, and organization can be distinct and diverse in different organisms.
Stimpson, KM; Sullivan, BA
- Brenner's Encyclopedia of Genetics: Second Edition
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International Standard Book Number 13 (ISBN-13)
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