Centromere

Book Section

Centromeres are essential to accurate segregation of genetic material in both meiosis and mitosis. Visually, the centromere is the site of constriction on metaphase chromosomes. Functionally, it is the site where the proteins of the kinetochore assemble to hold sister chromatids together and to guide chromosome movement during cell division. Despite such an essential role in chromosome stability, centromere sequence, structure, and organization can be distinct and diverse in different organisms.

Full Text

Duke Authors

Cited Authors

  • Stimpson, KM; Sullivan, BA

Published Date

  • February 27, 2013

Book Title

  • Brenner's Encyclopedia of Genetics: Second Edition

Start / End Page

  • 500 - 502

International Standard Book Number 13 (ISBN-13)

  • 9780123749840

Digital Object Identifier (DOI)

  • 10.1016/B978-0-12-374984-0.00219-9

Citation Source

  • Scopus