Book Section

Accurate chromosome segregation during cell division is essential for the health and viability of cells and organisms. Duplicated chromosomes attach to microtubules and subsequently disjoin to be equally partitioned to daughter cells. Failure to evenly apportion chromosomes is called nondisjunction and leads to aneuploidy, or a change in chromosome number. Abnormal chromosome number is associated with birth defects, mental retardation, reproductive defects, and cancer. This article draws upon recent studies in humans and model organisms to both define nondisjunction and discuss its molecular basis.

Full Text

Duke Authors

Cited Authors

  • Sullivan, BA

Published Date

  • February 27, 2013

Book Title

  • Brenner's Encyclopedia of Genetics: Second Edition

Start / End Page

  • 90 - 93

International Standard Book Number 13 (ISBN-13)

  • 9780123749840

Digital Object Identifier (DOI)

  • 10.1016/B978-0-12-374984-0.01056-1

Citation Source

  • Scopus