Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Published

Journal Article

To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS.

Full Text

Duke Authors

Cited Authors

  • Nicolas, A; Kenna, KP; Renton, AE; Ticozzi, N; Faghri, F; Chia, R; Dominov, JA; Kenna, BJ; Nalls, MA; Keagle, P; Rivera, AM; van Rheenen, W; Murphy, NA; van Vugt, JJFA; Geiger, JT; Van der Spek, RA; Pliner, HA; Shankaracharya, ; Smith, BN; Marangi, G; Topp, SD; Abramzon, Y; Gkazi, AS; Eicher, JD; Kenna, A; ITALSGEN Consortium, ; Mora, G; Calvo, A; Mazzini, L; Riva, N; Mandrioli, J; Caponnetto, C; Battistini, S; Volanti, P; La Bella, V; Conforti, FL; Borghero, G; Messina, S; Simone, IL; Trojsi, F; Salvi, F; Logullo, FO; D'Alfonso, S; Corrado, L; Capasso, M; Ferrucci, L; Genomic Translation for ALS Care (GTAC) Consortium, ; Moreno, CDAM; Kamalakaran, S; Goldstein, DB; ALS Sequencing Consortium, ; Gitler, AD; Harris, T; Myers, RM; NYGC ALS Consortium, ; Phatnani, H; Musunuri, RL; Evani, US; Abhyankar, A; Zody, MC; Answer ALS Foundation, ; Kaye, J; Finkbeiner, S; Wyman, SK; LeNail, A; Lima, L; Fraenkel, E; Svendsen, CN; Thompson, LM; Van Eyk, JE; Berry, JD; Miller, TM; Kolb, SJ; Cudkowicz, M; Baxi, E; Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, ; Benatar, M; Taylor, JP; Rampersaud, E; Wu, G; Wuu, J; SLAGEN Consortium, ; Lauria, G; Verde, F; Fogh, I; Tiloca, C; Comi, GP; Sorarù, G; Cereda, C; French ALS Consortium, ; Corcia, P; Laaksovirta, H; Myllykangas, L; Jansson, L; Valori, M; Ealing, J; Hamdalla, H; Rollinson, S; Pickering-Brown, S; Orrell, RW; Sidle, KC; Malaspina, A; Hardy, J; Singleton, AB; Johnson, JO; Arepalli, S; Sapp, PC; McKenna-Yasek, D; Polak, M; Asress, S; Al-Sarraj, S; King, A; Troakes, C; Vance, C; de Belleroche, J; Baas, F; Ten Asbroek, ALMA; Muñoz-Blanco, JL; Hernandez, DG; Ding, J; Gibbs, JR; Scholz, SW; Floeter, MK; Campbell, RH; Landi, F; Bowser, R; Pulst, SM; Ravits, JM; MacGowan, DJL; Kirby, J; Pioro, EP; Pamphlett, R; Broach, J; Gerhard, G; Dunckley, TL; Brady, CB; Kowall, NW; Troncoso, JC; Le Ber, I; Mouzat, K; Lumbroso, S; Heiman-Patterson, TD; Kamel, F; Van Den Bosch, L; Baloh, RH; Strom, TM; Meitinger, T; Shatunov, A; Van Eijk, KR; de Carvalho, M; Kooyman, M; Middelkoop, B; Moisse, M; McLaughlin, RL; Van Es, MA; Weber, M; Boylan, KB; Van Blitterswijk, M; Rademakers, R; Morrison, KE; Basak, AN; Mora, JS; Drory, VE; Shaw, PJ; Turner, MR; Talbot, K; Hardiman, O; Williams, KL; Fifita, JA; Nicholson, GA; Blair, IP; Rouleau, GA; Esteban-Pérez, J; García-Redondo, A; Al-Chalabi, A; Project MinE ALS Sequencing Consortium, ; Rogaeva, E; Zinman, L; Ostrow, LW; Maragakis, NJ; Rothstein, JD; Simmons, Z; Cooper-Knock, J; Brice, A; Goutman, SA; Feldman, EL; Gibson, SB; Taroni, F; Ratti, A; Gellera, C; Van Damme, P; Robberecht, W; Fratta, P; Sabatelli, M; Lunetta, C; Ludolph, AC; Andersen, PM; Weishaupt, JH; Camu, W; Trojanowski, JQ; Van Deerlin, VM; Brown, RH; van den Berg, LH; Veldink, JH; Harms, MB; Glass, JD; Stone, DJ; Tienari, P; Silani, V; Chiò, A; Shaw, CE; Traynor, BJ; Landers, JE

Published Date

  • March 21, 2018

Published In

Volume / Issue

  • 97 / 6

Start / End Page

  • 1268 - 1283.e6

PubMed ID

  • 29566793

Pubmed Central ID

  • 29566793

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2018.02.027

Language

  • eng

Conference Location

  • United States