Skip to main content

Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.

Publication ,  Journal Article
Coleman, JRI; Bryois, J; Gaspar, HA; Jansen, PR; Savage, JE; Skene, N; Plomin, R; Muñoz-Manchado, AB; Linnarsson, S; Crawford, G; Sullivan, PF ...
Published in: Mol Psychiatry
February 2019

Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with brain tissue and single cell gene expression data to identify tissues and cell types associated with intelligence. GWAS data for IQ (N = 78,308) were meta-analyzed with a study comparing 1247 individuals with mean IQ ~170 to 8185 controls. Genes associated with intelligence implicate pyramidal neurons of the somatosensory cortex and CA1 region of the hippocampus, and midbrain embryonic GABAergic neurons. Tissue-specific analyses find the most significant enrichment for frontal cortex brain expressed genes. These results suggest specific neuronal cell types and genes may be involved in intelligence and provide new hypotheses for neuroscience experiments using model systems.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Mol Psychiatry

DOI

EISSN

1476-5578

Publication Date

February 2019

Volume

24

Issue

2

Start / End Page

182 / 197

Location

England

Related Subject Headings

  • Temporal Lobe
  • Pyramidal Cells
  • Psychiatry
  • Polymorphism, Single Nucleotide
  • Multifactorial Inheritance
  • Male
  • Intelligence
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Coleman, J. R. I., Bryois, J., Gaspar, H. A., Jansen, P. R., Savage, J. E., Skene, N., … Breen, G. (2019). Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals. Mol Psychiatry, 24(2), 182–197. https://doi.org/10.1038/s41380-018-0040-6
Coleman, Jonathan R. I., Julien Bryois, Héléna A. Gaspar, Philip R. Jansen, Jeanne E. Savage, Nathan Skene, Robert Plomin, et al. “Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.Mol Psychiatry 24, no. 2 (February 2019): 182–97. https://doi.org/10.1038/s41380-018-0040-6.
Coleman JRI, Bryois J, Gaspar HA, Jansen PR, Savage JE, Skene N, et al. Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals. Mol Psychiatry. 2019 Feb;24(2):182–97.
Coleman, Jonathan R. I., et al. “Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.Mol Psychiatry, vol. 24, no. 2, Feb. 2019, pp. 182–97. Pubmed, doi:10.1038/s41380-018-0040-6.
Coleman JRI, Bryois J, Gaspar HA, Jansen PR, Savage JE, Skene N, Plomin R, Muñoz-Manchado AB, Linnarsson S, Crawford G, Hjerling-Leffler J, Sullivan PF, Posthuma D, Breen G. Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals. Mol Psychiatry. 2019 Feb;24(2):182–197.

Published In

Mol Psychiatry

DOI

EISSN

1476-5578

Publication Date

February 2019

Volume

24

Issue

2

Start / End Page

182 / 197

Location

England

Related Subject Headings

  • Temporal Lobe
  • Pyramidal Cells
  • Psychiatry
  • Polymorphism, Single Nucleotide
  • Multifactorial Inheritance
  • Male
  • Intelligence
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease